中国兽药杂志2025，Vol.59Issue(2)：43-49,7.DOI:10.11751/ISSN.1002-1280.2025.2.06
卡洛芬注射液在奶牛体内的残留消除研究
Study on Residual Elimination of Carprofen Injection in Dairy Cows
贾兴 1黄凯 1耿智霞 1瞿红颖 1宋婷婷 1刘静 1郭李珉 1曹兴元2
作者信息
- 1. 河北远征药业有限公司,石家庄 050041||河北省兽药工程技术研究中心,石家庄 050041||石家庄市兽药技术创新中心,石家庄 050041
- 2. 中国农业大学,北京 10094
- 折叠
摘要
Abstract
The purpose of this study is to analyze the residual elimination rule of carprofen injection in dairy cows and determine the withdrawal period.24 healthy dairy cows were administered carprofen at a dose of 1.4 mg/kg body weight via subcutaneous injection in the neck.Muscle,liver,fat and kidney samples were collected from cows at 12 h,3 d,7 d,14 d and 21 d time points after a single administration.After processing the tissue samples,the content of carprofen was detected by ultra-high performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).The methodological results showed that the method had a good linear relationship within the addtion range of 200～2000 ng/mL,and the correlation coefficient r≥0.99.The average recoveries of carprofen in different tissues were between 87.79%and 113.83%,the intra batch and inter batch coefficients of variation were less than 15%.Calculated by the calculation software WT1.4,the withdrawal periods of muscle,liver,kidney,and fat were 7.75 d,10.04 d,10.25 d,and 7.54 d,respectively.The residue of the injection site at 21 d was below the MRL in muscle.Therefore,carprofen injection should be used in dairy cows according to the recommended dosing regimen,and it is recommended to set the withdrawal period at 21 d.关键词
卡洛芬/奶牛/残留消除/休药期Key words
carprofen/dairy cows/residual elimination/withdrawal period分类
农业科技引用本文复制引用
贾兴,黄凯,耿智霞,瞿红颖,宋婷婷,刘静,郭李珉,曹兴元..卡洛芬注射液在奶牛体内的残留消除研究[J].中国兽药杂志,2025,59(2):43-49,7.
