中医康复2025，Vol.2Issue(4)：66-71,6.DOI:10.19787/j.issn.2097-3128.2025.04.011
重复经颅磁刺激对脑卒中后血管性痴呆患者认知功能的疗效研究
Effects of Repeated Transcranial Magnetic Stimulation on Cognitive Function in Patients with Vascular Dementia after Stroke
摘要
Abstract
Objective:To investigate the effect and mechanism of repeated transcranial magnetic stimulation(rTMS)on cognitive function in patients with vascular dementia.Methods:60 patients with vascular dementia were randomly divided into conventional treatment group(CT group,n=30)and repeated transcranial magnetic stimulation group(rTMS group,n=30)by computer.Patients in both groups received routine rehabilitation training,including motor function training,daily living activities training and cognitive function training.Patients in the rTMS group also received rTMS intervention once a day,5 days a week for 4 weeks.The cognitive function(MMSE and MoCA),activities of daily living(MBI)and quality of life(SS-QOL)of patients were assessed before and af-ter treatment,and the amplitude and latency of event-related potential P300 were recorded in two groups.Results:There were no sig-nificant differences in MMSE,MoCA,MBI,SS-QOL score,P300 latency and amplitude between the two groups before treatment(P>0.05).After treatment,the cognitive function,the ability of daily living,the quality of life and the amplitude of P300 were signifi-cantly improved(P<0.05),while the latency of P300 was shortened(P<0.05).Besides,MMSE,MoCA,MBI,SS-QOL score and P300 amplitude in rTMS group were higher than those in CT group(P<0.05),but P300 latency was shorter than that in CT group,the differences were statistically significant(P<0.05).Conclusion:rTMS can significantly improve cognitive function,daily living ability and quality of life in patients with vascular dementia,which may be related to the shortened latency and increased amplitude of P300.关键词
血管性痴呆/重复经颅磁刺激/认知功能/MMSE/MoCA/P300/波幅/潜伏期Key words
vascular dementia/repeated transcranial magnetic stimulation/cognitive function/MMSE/MoCA/P300/amplitude/la-tency分类
临床医学引用本文复制引用
周甜甜,苏文杰,连松勇,林友聪..重复经颅磁刺激对脑卒中后血管性痴呆患者认知功能的疗效研究[J].中医康复,2025,2(4):66-71,6.基金项目
泉州市医疗卫生领域指导性科技计划项目(2023N010S) （2023N010S）
