常熟理工学院学报2025，Vol.39Issue(2)：30-37,8.
响应面法优化黄连地榆复方软膏剂处方及体外抑菌效果研究
Optimization of Chinese Herbal Ointment Formulation and Its Antibacterial Effect in Vitro by Response Surface Methodology
摘要
Abstract
In this study,the appearance,coating malleability,centrifugation,heat and cold stability were used as comprehensive evaluation criteria,and the formulation of Chinese herbal ointment was optimized by single factor experiment and Box-Behnken design.The antibacterial effects of Coptis chinensis and San guisorba officinalis on specific microorganisms were investigated by Oxford cup method.As the results show under the experimental conditions,the best prescription of Chinese herbal scald cream was:stearic acid 14.00%glycerol monostearate 3.50%,white Vaseline 1.00%,lanolin 5.40%,liquid paraffin 6.00%,triethanolamine 0.46%.In the vitro antibacterial experiment,the drug loading composition selected was a combination of Coptis chinensis and San guisorba officinalis with the ratio of 9:1.The Chinese herbal scald ointment has better heat and cold resistance and centrifugal stability,and the effective Chinese herbal ingedients added have good antibacterial properties.This study provides basic data for the formulation optimization of Chinese herbal ointment.关键词
黄连/地榆/软膏剂/处方优化/Box-Behnken/牛津杯法Key words
Coptis chinensis/Ulmus officinalis/ointment/matrix component optimization/Box-Behnken/Oxford cup method分类
中医学引用本文复制引用
邰广鑫,邰洪云,刘欣语,马慧敏,潘红英,张晶..响应面法优化黄连地榆复方软膏剂处方及体外抑菌效果研究[J].常熟理工学院学报,2025,39(2):30-37,8.基金项目
常熟理工学院大学生创新创业训练计划项目"中草药烫伤膏制备工艺及相关性能研究"(XJDC2022195) （XJDC2022195）
常熟理工学院生物与食品工程学院大学生创新创业训练计划项目"美白凝胶型面膜的制作工艺研究" （）
