儿科药学杂志2025，Vol.31Issue(3)：24-27,4.DOI:10.13407/j.cnki.jpp.1672-108X.2025.03.006
人免疫球蛋白联合机械通气策略在儿童重度肺源性急性呼吸窘迫综合征抢救中的应用
Application of Human Immunoglobulin Combined with Mechanical Ventilation Strategy in the Rescue of Severe Pulmonary Acute Respiratory Distress Syndrome in Children
摘要
Abstract
Objective:To explore the application of human immunoglobulin combined with mechanical ventilation strategy in the rescue of severe pulmonary acute respiratory distress syndrome in children.Methods:Forty children with severe pulmonary acute respiratory distress syndrome admitted into Anhui Children's Hospital from 2017 to 2022 were extracted to be divided into the control group and observation group via the envelope method.As 10 cases died during the course,30 cases of children completed the research.Sixteen children in the control group were treated with mechanical ventilation,while 16 cases in the observation group received human immunoglobulin on the basis of the control group.The duration of mechanical ventilation,length of stay,blood gas indicators,serum inflammatory factors,lung function,and incidence of complications were compared between two groups.Results:The mechanical ventilation time and length of stay in the observation group were shorter than those in the control group.The differences of pH,partial pressure of carbon dioxide in artery(PaCO2),arterial partial pressure of oxygen(PaO2),forced expiratory volume in one second(FEV1),FEV1％and peak expiratory flow(PEF)before and after treatment in the observation group were greater than those in the control group.After treatment,the levels of interleukin(IL)-10 in observation group were higher than those in control group,and the levels of tumour necrosises factor(TNF)-α,intercellular adhesion molecule-1(ICAM-1)and IL-6 were lower than those in control group(P＜0.05).The total incidence of complications between two groups showed no statistically significant difference(P＞0.05).Conclusion:The combination of human immunoglobulin and mechanical ventilation strategy in the rescue of severe pulmonary acute respiratory distress syndrome in children can shorten the treatment time,improve lung function recovery,and reduce the inflammatory response of the body,without increasing the occurrence of adverse drug reactions,which is worthy of clinical application.关键词
人免疫球蛋白/机械通气/儿童/重度肺源性急性呼吸窘迫综合征/血气指标/肺功能Key words
human immunoglobulin/mechanical ventilation/children/severe pulmonary acute respiratory distress/blood gas indicator/lung function分类
临床医学引用本文复制引用
经涛,吴优,徐凤琴,李小双,徐卫华..人免疫球蛋白联合机械通气策略在儿童重度肺源性急性呼吸窘迫综合征抢救中的应用[J].儿科药学杂志,2025,31(3):24-27,4.基金项目
安徽省自然科学基金面上项目,编号2108085MH268. （）
