儿科药学杂志2025，Vol.31Issue(3)：34-38,5.DOI:10.13407/j.cnki.jpp.1672-108X.2025.03.009
1例拉考沙胺致儿童药物性肝损伤病例分析并文献复习
A Case of Drug-Induced Liver Injury Induced by Lacosamide in Children and Literature Review
摘要
Abstract
Objective:To probe into the correlation and characteristics of drug-induced liver injury(DILI)induced by lacosamide(LCM),so as to provide reference for the safe use of LCM.Methods:A case of a 9-year-old child in a certain hospital who developed DILI induced by LCM for epilepsy treatment was analyzed.Relevant literature at home and abroad were reviewed.Results:A total of 5 domestic and foreign literature related to DILI induced by LCM were retrieved.This article was the first report of children with DILI induced by LCM.The analysis showed that DILI of different degrees may occur during the treatment of LCM,mainly liver injury type,and liver function returned to the normal state after drug withdrawal or symptomatic treatment.Conclusion:There are few reports of DILI induced by LCM,and the pathological mechanism of liver injury is not yet clear.In clinical practice,the possibility of DILI induced by LCM should be recognized,and changes in liver function should be monitored during medication.关键词
拉考沙胺/药物性肝损害/儿童/药品不良反应Key words
lacosamide/drug-induced liver injury/children/adverse drug reaction分类
药学引用本文复制引用
牛瑞,王熊,李欣坪,徐晓微,王婧雯,葛洁..1例拉考沙胺致儿童药物性肝损伤病例分析并文献复习[J].儿科药学杂志,2025,31(3):34-38,5.基金项目
国家自然科学基金资助项目,编号72074218. （）
