儿科药学杂志2025，Vol.31Issue(3)：39-44,6.DOI:10.13407/j.cnki.jpp.1672-108X.2025.03.010
146例新生儿万古霉素谷浓度监测及其影响因素分析:一项单中心回顾性观察研究
Monitoring of Trough Concentration of Vancomycin in 146 Neonates and Analysis of Its Influencing Factors:a Single Center,Retrospective Observational Study
摘要
Abstract
Objective:To probe into the influencing factors of low compliance rate of vancomycin trough concentration monitoring in critically ill neonates.Methods:Neonates with vancomycin treatment admitted into the Northwest Women's and Children's Hospital from Dec.2018 to Dec.2023,aged ≤28 d treated with intravenous vancomycin,and with gestational age ≥26 weeks were enrolled.Results:A total of 146 patients were included,and 15.06％(22/146)of patients had a trough concentration of vancomycin＜5 mg/L.Univariate regression analysis showed that gestational age,body weight,height,vancomycin daily dose were significantly correlated with trough concentration of vancomycin(P＜0.05).Multiple linear regression analysis showed that gestational age,body weight,and vancomycin daily dose were independent influencing factors for low trough concentration of vancomycin(P＜0.05).Conclusion:The daily dose,gestational age and body weight of vancomycin are the important influencing factors affecting the compliance rate of trough concentration of vancomycin monitoring in neonates,especially in severe neonates.关键词
万古霉素/谷浓度/影响因素/新生儿Key words
vancomycin/trough concentration/influencing factors/neonates分类
医药卫生引用本文复制引用
陈慧,刘振国,巨康璐,常瑛,郭波..146例新生儿万古霉素谷浓度监测及其影响因素分析:一项单中心回顾性观察研究[J].儿科药学杂志,2025,31(3):39-44,6.基金项目
西安市创新能力支撑计划,编号23YXYJ0143. （）
