福建师范大学学报（自然科学版）2025，Vol.41Issue(2)：9-15,7.DOI:10.12046/j.issn.1000-5277.2024100026
弥漫性胶质瘤患者生存预后评估
Survival Prognosis Assessment Study in Patients with Diffuse Glioma:Based on MRI Radiomics Features
摘要
Abstract
A model based on radiomics features from contrast-enhanced T1-weighted MRI was developed and validated to predict postoperative survival prognosis in patients with diffuse glioma.Radiomics features were extracted from the necrotic tumor core necrosis,peritumoral edema and en-hancing tumor regions using preoperative MRI data from 387 patients with diffuse glioma,and a LASSO-Cox regression model was employed for feature selection and model construction.The data were randomly divided into a training group(80%;309 patients)and a validation group(20%;78 patients).The model was developed in the training group and its predictive performance was validated in the validation group.The model's C-index was 0.72 in the training group and 0.69 in the validation group.The 1-year,2-year,and 3-year AUCs were 0.79,0.81,and 0.86 in the training group,and 0.72,0.76,and 0.81 in the validation group,respectively.The study demonstrated that radiomics features based on contrast-enhanced T1-weighted MRI can effectively predict the postoperative progno-sis of patients with diffuse gliomas,providing a basis for clinical decision-making.关键词
弥漫性胶质瘤/磁共振成像/影像组学/生存分析/预后/LASSO-Cox回归模型Key words
diffuse glioma/magnetic resonance imaging/radiomics/survival analysis/prog-nosis/LASSO-Cox regression model分类
数理科学引用本文复制引用
叶大涵,谢剑锋,陈晓平..弥漫性胶质瘤患者生存预后评估[J].福建师范大学学报（自然科学版）,2025,41(2):9-15,7.基金项目
国家自然科学基金项目(12401380) （12401380）
福建省卫生健康重大科研专项(2021ZD01001) （2021ZD01001）
福建省直单位教育和科研专项资金(闽财指[2022]639 号) （闽财指[2022]639 号）
福建省卫生健康中青年领军人才培养项目 （）
福建省教育科学规划 2024 年教育考试招生重点专项课题(FJJKS24-02,福建省教育考试院资助) （FJJKS24-02,福建省教育考试院资助）
福建理工大学科研启动基金(GY-S24002) （GY-S24002）
