康复学报2025，Vol.35Issue(1)：36-43,8.DOI:10.3724/SP.J.1329.2025.01005
基于功能性近红外光谱技术观察注意力缺陷多动障碍儿童脑功能连接和激活特征
Observation of Brain Functional Connectivity and Activation Characteristics in Children with Attention Deficit and Hyperactivity Disorder Based on Functional Near-Infrared Spectroscopy
摘要
Abstract
Objective To explore the characteristics of functional connectivity in the prefrontal cortex of children with atten-tion deficit hyperactivity disorder(ADHD)at rest and the level of brain functional activation during the Go/No-go task using func-tional near and infrared spectroscopy(fNIRS).Methods Twenty-one children with ADHD who visited Kunming Children's Hospi-tal from January 2022 to August 2023 were selected as the study subjects,namely the ADHD group.Meanwhile,20 typically deve-loping children matched in age,intelligence quotient(IQ),and gender were selected as the typically developing group(TD group).The scores of the SNAP-Ⅳ Scale(Parent Version)were compared between the two groups,and fNIRS was used to collect 10-min-ute resting-state data of the prefrontal cortex of the children.Based on the concentrations of oxyhemoglobin(HbO2),deoxyhemoglo-bin(HbR)and total hemoglobin(HbT)collected,the functional connectivity strength at rest was calculated for both groups.Mean-while,the Go/No-go task was selected to evaluate children's response inhibition function,and fNIRS was applied to detect the chang-es blood oxygen concentration levels in prefrontal cortex of the two groups of children during the Go/No-go task,and the brain func-tional activation levels of the two groups during the task were calculated.Results Compared with the TD group,the attention defi-cit score,hyperactivity-impulsivity score,and oppositional defiant score of the ADHD group were higher,and the differences were statistically significant(P<0.05).The fNIRS findings revealed that compared with the TD group,the functional connectivity strength among all channels and the resting-state brain functional connectivity strength of the left dorsolateral prefrontal cortex,right dorsola-teral prefrontal cortex,left medial prefrontal cortex,and right medial prefrontal cortex in the ADHD group were lower(P<0.05).By comparing the behavioral performance scores during the Go/No-go task,the ADHD group had lower accuracy in the No-go block compared with the TD group(P<0.05).There were no statistically significant differences in the accuracy rate and reaction time during the Go block and the reaction time of the No-go block between the two groups(P>0.05).During the Go/No-go task,compared with the TD group,the average HbO2 concentrations of the left dorsolateral prefrontal cortex,right dorsolateral prefrontal cortex,left me-dial prefrontal cortex,and right medial prefrontal cortex in the ADHD group were lower(P<0.05).The SNAP-Ⅳ Scale scores of the two groups were negatively correlated with the average HbO2 concentration of the prefrontal lobe in the Go/No-go task(P<0.05).Conclusion fNIRS can effectively detect the abnormal characteristics of the prefrontal cortex in children with ADHD at rest and during the task state.The main abnormalities appear in the left and right dorsolateral prefrontal cortices and the left and right medial prefrontal cortices.These findings provide imaging evidence for an in-depth understanding of the neuropathological mechanism of ADHD and are expected to provide new ideas and targets for the subsequent formulation of precise diagnosis and intervention strate-gies.关键词
注意力缺陷多动障碍/功能性近红外光谱技术/血氧浓度/功能连接强度/脑功能激活/神经病理机制Key words
attention deficit and hyperactivity disorder/functional near infrared spectroscopy/blood oxygen concentration/functional connectivity strength/brain function activation/neuropathological mechanisms引用本文复制引用
王静,刘芸,黄浩宇,吴金庭,邹卓,陈颖娟,魏贤召,苏杭..基于功能性近红外光谱技术观察注意力缺陷多动障碍儿童脑功能连接和激活特征[J].康复学报,2025,35(1):36-43,8.基金项目
云南省科技厅科技计划项目昆医联合专项(202401AY070001-022) （202401AY070001-022）
云南省徐开寿专家工作站(202405AF140103) （202405AF140103）
云南省教育厅科学研究基金(2024J0303) （2024J0303）
昆明市卫生科技人才培养项目医学科技学科后备人才培养计划[2022-SW(后备)005] （后备）
昆明市卫生科研课题(2023-16-01-001) （2023-16-01-001）
