分析测试学报2025，Vol.44Issue(3)：540-543,4.DOI:10.12452/j.fxcsxb.240614131
基于ICP-MS测定硼中子俘获治疗中全血硼浓度的方法探究
Study on Determination of Boron Concentration in Human Blood for Boron Neutron Capture Therapy by Indictive Coupled Plasma Mass Spectrometry
摘要
Abstract
In this paper,based on inductively coupled plasma mass spectrometry(ICP-MS)technol-ogy,a method for measuring the boron concentration in human whole blood was established.Whole blood samples were diluted directly with a mixture solution of 0.1%nitric acid and 0.1%Triton X-100,and the system applicability,quantitative range,precision and accuracy,matrix effect and so on of the method were verified.The results showed that the method has the quantitative range of 2-50 µg/mL for 10 B and has good precision and accuracy and no matrix effect.This method has the charac-teristics of easy operation,rapid detection and usable data,and is suitable for real-time monitoring of 10 B concentration in blood of patients during BNCT treatment.关键词
ICP-MS/血硼浓度/硼中子俘获治疗(BNCT)/临床Key words
ICP-MS/blood boron concentration/boron neutron capture therapy(BNCT)/clinical分类
化学化工引用本文复制引用
傅霜,孙晓萍,卞亚,陈腊梅,周平..基于ICP-MS测定硼中子俘获治疗中全血硼浓度的方法探究[J].分析测试学报,2025,44(3):540-543,4.基金项目
国家重点研发计划政府间国际科技创新合作重点项目中日项目(2022YFE0107800) （2022YFE0107800）
