分子影像学杂志2025，Vol.48Issue(2)：138-144,7.DOI:10.12122/j.issn.1674-4500.2025.02.02
针灸原发性痛经患者的脑功能网络分析:基于rs-fMRI数据
Brain function network analysis of patients with primary dysmenorrhea after acupuncture and moxibustion:based on rs-fMRI data
摘要
Abstract
Objective To investigate the changes in brain functional network before and after acupuncture in patients with primary dysmenorrhea(PDM)using resting-state functional MRI(rs-fMRI)graph theory and edge analysis.Methods Thirty-five women with PDM were enrolled in this study,and the patients with PDM were treated with acupuncture 7 days before menstruation until the onset of menstruation,taking Guanyuan point and bilateral Sanyinjiao for 30 min per day.The data of visual analogue score(VAS),the cox menstrual symptom score(CMSS),self-rating anxiety score(SAS),self-rating depression score(SDS)and brain fMRI of PDM patients before and after acupuncture and moxibustion were collected.GRETNA software was used to analyze the brain function data of PDM patients before and after acupuncture and moxibustion by graph theory and edge analysis,and correlated with the clinical score.Results After acupuncture,the menstrual VAS,CMSS,SAS,and SDS were reduced in PDM patients(P<0.05).The global efficiency of brain networks increases,while the mean clustering coefficient and average path length decrease(P<0.05).Functional connectivity(FC)was enhanced between the right insula and the right middle frontal gyrus,and between the left rolandic operculum and the right superior temporal gyrus.between the right precentral gyrus and bilateral thalamus and the right putamen,between the right postcentral gyrus and the left middle frontal gyrus and the left supplementary motor area,between the right anterior cingulate and the left anterior cingulate and right posterior cingulate,between the left precentral gyrus and the left thalamus,between the right posterior cingulate gyrus and the left middle temporal gyrus,and between the left postcentral gyrus and the left thalamus with diminished FC(P<0.001).the change in FC between the left precentral gyrus and the left thalamus was positively correlated with the change in SDS(r=0.516,P=0.002).Conclusion The present acupuncture therapy had good efficacy.Acupuncture and moxibustion may improve the integration efficiency of pain related information in the brain network of PDM patients,and inhibit the transmission efficiency of pain related information.The neural pathways involved in the onset of acupuncture and moxibustion may be the thalamus sensorimotor cortex circuit,cingulate cortex circuit,and salience network.The three main lines jointly shoulder the tasks of analgesia,emotional relief,and painful attention transfer.关键词
原发性痛经/针灸/功能MRI/脑网络Key words
primary dysmenorrhea/acupuncture and moxibustion/functional MRI/brain network引用本文复制引用
张中旭,马萧童,周锋,杨艺超,王志群,郑运松..针灸原发性痛经患者的脑功能网络分析:基于rs-fMRI数据[J].分子影像学杂志,2025,48(2):138-144,7.基金项目
陕西省科学技术厅重点研发计划项目(2024SF-YBXM-524) （2024SF-YBXM-524）
秦创原中医药产业创新聚集区项目(L2024-QCY-ZYYJJQ-Y07) （L2024-QCY-ZYYJJQ-Y07）
