甘肃中医药大学学报2025，Vol.42Issue(1)：14-19,6.DOI:10.16841/j.issn1003-8450.2025.01.03
沙米茎秆和沙米全粉饼干对肥胖模型大鼠的减肥效果研究
Study on the weight loss effect of Agriophyllum Squarrosum stem and whole powder biscuits on obese model rats
摘要
Abstract
Objective To evaluate the weight loss effects of Agriophyllum squarrosum stem and whole powder biscuits on obese model rats.Methods High-fat diet was used to feed SD rats to establish the rat obesity model.The experimental rats were randomly divided into five groups:blank control group,model control group,oat konjac group,Agriophyllum squarrosum whole powder group,and Agriophyllum squarrosum stem group,with 8 rats in each group.The blank control group was fed with maintenance diet,while the other four groups were fed with high-fat diet,oat konjac biscuits,whole powder biscuits of Agriophyllum squarrosum,and stem biscuits of Agriophyllum squar-rosum mixed with maintenance diet.The body weight,neck circumference,waist circumference,Lee's index,fat-to-body ratio,and liver index of the rats were measured and calculated.The levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)in the serum of the rats were determined by enzymatic method.HE staining was used to observe the pathological changes of liver and kidney tissues under a microscope.Results By the fifth week of administering a high-fat diet,the body weight growth rate of rats in each model group exhibited a notable increase compared to the blank control group,with these differences being statistically significant(P＜0.05).At both the fifth and fifteenth weeks of the experiment,the mo-del control group demonstrated marked elevations in TC and LDL-C levels,along with a significant reduction in HDL-C levels,compared to the blank control group.These disparities were statistically significant(P＜0.05).At the fifteenth week,the Agriophyllum squarrosum stem group exhibited significantly lower TC and LDL-C levels than both the model control group and the Agriophyllum squarrosum whole powder group,with these differences being statisti-cally significant(P＜0.05).When compared to the blank control group,the model control group showed substantial increases in neck and waist circumference,as well as elevated Lee's index and fat-to-body ratio,with all these changes being statistically significant(P＜0.05).Conversely,the Agriophyllum squarrosum whole powder group,the Agriophyllum squarrosum stem group,and the oat konjac group did not demonstrate significant changes in neck or waist circumference compared to the model control group,with these differences being non-significant(P＞0.05).However,the Agriophyllum squarrosum stem group exhibited significantly lower Lee's index and fat-to-body ratio than both the model control group and the Agriophyllum squarrosum whole powder group,with these differences being statistically significant(P＜0.05).The extent of liver fatty lesions was less severe in the Agriophyllum squarro-sum stem group compared to the model control group.Conclusion The biscuits made from the stem of Agriophyllum squarrosum have certain effects on weight loss,liver protection,and lipid regulation,while the biscuits made from the whole powder of Agriophyllum squarrosum do not have a weight loss effect.关键词
肥胖/沙米全粉/沙米茎秆/减肥/降脂/保肝/大鼠/实验研究Key words
obesity/Agriophyllum squarrosum whole powder/Agriophyllum squarrosum stem/weight loss/lipid regulation/liver protection/rats/experimental study分类
医药卫生引用本文复制引用
贾孝荣,张桂芳,徐贵静,史亚丽,史彦斌..沙米茎秆和沙米全粉饼干对肥胖模型大鼠的减肥效果研究[J].甘肃中医药大学学报,2025,42(1):14-19,6.基金项目
甘肃省兰州市人才创新创业项目(2019-RC-44). （2019-RC-44）
