中国妇幼健康研究2025，Vol.36Issue(3)：21-29,9.DOI:10.3969/j.issn.1673-5293.2025.03.004
miRNA-182水平与宫颈癌患者临床病理特征及预后的关系
Relationship between miRNA-182 level and clinicopathological features and prognosis of patients with cervical cancer
摘要
Abstract
Objective To investigate the relationship between miRNA-182 levels and the clinical pathological characteristics and prognosis of cervical cancer patients.Methods A total of 112 cervical cancer patients treated at the First Affiliated Hospital of Hainan Medical College from February 2021 to June 2023 were selected as the study subjects,and they were divided into good prognosis group(78 cases)and poor prognosis group(34 cases)according to the adverse outcome of death during the 180-day follow-up of the study subjects.The clinical characteristics of patients with different miRNA-182 levels were compared,the prognosis of patients with different miRNA-182 levels was analyzed,the dose-response relationship between miRNA-182 levels and the probability of adverse prognosis was studied,and the decision curve analysis(DCA)between miRNA-182 levels and prognosis was analyzed.Results Compared with the low-level miRNA-182 group,the patients in the middle-to-high-level group were older,with a higher proportion of smoking history,diabetes history,International Federation of Obstetrics and Gynecology(FIGO)tumor stage Ⅲ-Ⅳ,squamous cell carcinoma,adjuvant therapy administration,lymph node metastasis,alcohol history and vaginal invasion,and the differences were statistically significant(x2/F values ranging from 3.650 to 15.118,P＜0.05).Compared with the good prognosis group,the miRNA-182 level was higher in the poor prognosis group,and the difference was statistically significant(t=2.652,P＜0.05).The Cox regression model showed that the risk of poor prognosis in the low-and middle-level groups was lower than that in the high-level group(HR values ranging from 0.125 to 0.566,P＜0.05).The results of dose-response relationship showed that miRNA-182 level was significantly positively correlated with poor prognosis.The results of DCA curve analysis showed that the smaller the high-risk threshold within 1％～70％,the higher the net benefit rate and the greater the clinical significance.Conclusion The level of miRNA-182 has a good predictive value for the prognosis of cervical cancer patients,which is worthy of clinical promotion.关键词
miRNA-182/宫颈癌/临床病理特征/预后Key words
miRNA-182/cervical cancer/clinicopathological feature/prognosis分类
预防医学引用本文复制引用
高飞,王永存,尹纪来,王大平..miRNA-182水平与宫颈癌患者临床病理特征及预后的关系[J].中国妇幼健康研究,2025,36(3):21-29,9.基金项目
海南医学院第一附属医院2020年度青年培育基金(HYYFYPY202004) （HYYFYPY202004）
