国际口腔医学杂志2025，Vol.52Issue(2)：246-256,11.DOI:10.7518/gjkq.2025028
磷脂酰肌醇3激酶相关放射抵抗机制在口腔鳞状细胞癌中的研究进展
Research progress on phosphatidylinositol 3-kinase-mediated radioresistance in oral squamous cell carcinoma
摘要
Abstract
Oral squamous cell carcinoma(OSCC)is the most common type of malignant tumors in craniofacial region with a high malignancy.Radiotherapy,a vital means of integrated sequential therapy for OSCC,often has good treating ef-ficacy for primary tumor.However,it still remains susceptible to the incidence of tumor recurrence and metastasis with high mortality post-radiotherapy.The main reason lies in the significant radioresistance of partial OSCC.The cancer cells survived from Radiotherapy are able to obtain enhanced proliferation,invasion and migration,occur epithelial-mesenchymal transformation,and even acquire cancer stem cell phenotype.Phosphatidylinositol 3-kinase/pro-tein kinase B(PI3K/PKB,often known as PI3K/Akt)signaling pathway and its signaling components widely engaged in regulating the development and prognosis of OSCC,has been reported to promote radioresistance of OSCC when activated.However,the specific mechanism still needs further identification.This review focuses on the mechanism of PI3K signaling and radioresistance in OSCC,and summarize the current research progress from three aspects including cancer cell,cancer stem cell and tumor microenvi-ronment,to discuss the molecular mechanism of PI3K-mediated radioresistance,hoping to provide effective potential mo-lecular target for better radiosensitivity and prognosis of OSCC.关键词
口腔鳞状细胞癌/放射疗法/辐射耐受性/磷脂酰肌醇3激酶Key words
oral squamous cell carcinoma/radiotherapy/radioresistance/phosphatidylinositol 3-kinase分类
临床医学引用本文复制引用
卢妍蓓,李正娟,雷蕾,罗晶晶..磷脂酰肌醇3激酶相关放射抵抗机制在口腔鳞状细胞癌中的研究进展[J].国际口腔医学杂志,2025,52(2):246-256,11.基金项目
National Natural Science Foundation of China(82001061) （82001061）
Sichuan Natural Science Foundation(2022NS-FSC1377) （2022NS-FSC1377）
Research Funding from West China School/Hospital of Stomatology,Sichuan University(RCDWJS2024-9)国家自然科学基金(82001061) （RCDWJS2024-9）
四川省自然科学基金(2022NSFSC1377) （2022NSFSC1377）
四川大学华西口腔医学院(华西口腔医院)科研经费资助项目(RCDWJS2024-9) （华西口腔医院）
