国际口腔医学杂志2025，Vol.52Issue(2)：257-262,6.DOI:10.7518/gjkq.2025021
唾液腺微分泌性腺癌临床病理的研究进展
Clinical pathological study on the microsecretory adenocarcinoma of salivary glands
摘要
Abstract
Microsecretory adenocarcinoma(MSA)is a new entity in the 5th edition of the Word Health Organization(WHO)Classification of Head and Neck Tumors.It is a low-grade malignant epithelial tumor of the salivary gland and has unique histological characteristics,immunoprofile,and molecular features.Histologically,MSA shows many growth patterns,including microcystic,cribriform,tubular,and cords,with abundant basophilic secretions in the lumens.The tu-mor is composed of a single population of intercalated duct-like cells.The stroma is fibromyxoid.For its immunoprofile,MSA is positive for SOX10,S100,and p63 and negative for p40,calponin,and mammaglobin.Meanwhile,MSA is va-riable for smooth muscle actin and exhibits a specific MEF2C∶∶SS18 gene fusion.The differential diagnosis for MSA in-cludes secretory carcinoma,sclerosing microcystic adenocarcinoma,polymorphic adenocarcinoma,adenoid cystic carci-noma,and secretory myoepithelial carcinoma.关键词
微分泌性腺癌/唾液腺肿瘤/MEF2C::SS18基因融合Key words
microsecretory adenocarcinoma/sali-vary tumor/MEF2C::SS18 gene fusion分类
医药卫生引用本文复制引用
揭伟萍,胡济安,李怡宁..唾液腺微分泌性腺癌临床病理的研究进展[J].国际口腔医学杂志,2025,52(2):257-262,6.基金项目
Medical Health Science and Technology Program Project in Zhejiang Province(2022516638,2017KY448) （2022516638,2017KY448）
Zhejiang Provincial Department of Education General Research Project(Y202147707)浙江省医药卫生科技计划项目(2022516638,2017KY448) （Y202147707）
浙江省教育厅一般科研项目(Y202147707) （Y202147707）
