摘要
Abstract
Medication-related osteonecrosis of the jaw(MRONJ)is a serious infection and necrotizing disease of the jaw.It is caused by the use of antiresorptive and anti-angiogenic drugs in the treatment of cancer,osteoporosis,and other diseases.MRONJ has serious clinical symptoms and an increasing yearly incidence,seriously affecting the quality of life of patients.No consensus regarding the treatment principle of MRONJ has not been reached.To date,active surgical treat-ment is recommended,but the surgical focus is mainly on the removal of necrotic bone.The effective closure of soft tis-sue wounds has not attracted enough attention,resulting in poor postoperative oral mucosal healing,wound dehiscence,bone surface exposure,repeated infection,and other complications,and the treatment effect is poor.Therefore,the effec-tive management of soft tissue wounds after lesion resection is another key step affecting prognosis and has become a to-pic of great interest in clinical practice.This article summarizes various soft tissue wound closure techniques after MRONJ surgery,including double-layer soft tissue suture closure,pedicle buccal fat pad flap,nasolabial flap,mylohyoid flap and submandibular gland transposition,submental island flap,free skin flap transplantation,and surgical com-bined adjuvant therapy.This study discussed progress in clinical research on the applicability and advantages and disadvantages of these techniques to provide reference for improving the clinical treatment of MRONJ.关键词
药物相关性颌骨坏死/双膦酸盐/颊脂垫/颏下动脉瓣Key words
medication-related osteonecrosis of the jaw/bisphosphonate/buccal fat pad/submental island flap分类
口腔医学
