摘要
Abstract
Objective To compare the dosimetry and efficacy differences among Hyperarc,volume modulated arc therapy(VMAT),intensity modulated radiation therapy(IMRT),and three-dimensional conformal radiation therapy(3DCRT)for the treatment of multiple brain metastases.Methods A total of 168 patients with multiple brain metastases were prospectively selected and randomly divided into 4 groups(n=42),each receiving treatment plans designed using Hyperarc,VMAT,IMRT,or 3DCRT.One-way ANOVA,Kruskal Wallis test,and chi-square test were used to compare the clinical data and treatment efficacy,as well as the dosimetric parameters of the planning target volume[homogeneity index(HI),conformity index(CI),gradient index(GI)],organ at risk dose[maximum dose(Dmax)and average dose(Dmean)to bilateral crystals and brainstem],and monitor units and beam delivery time,among the 4 groups.Results The treatment efficacy of the Hyperarc group was significantly higher than that of the VMAT,IMRT,and 3DCRT groups(P＜0.05).Compared with the other three groups,the Hyperarc group had lower HI,GI,and Dmax/Dmean for the bilateral lenses and brainstem,while Dmean and CI of target volume were higher(all P＜0.05).The VMAT and IMRT groups exhibited lower HI,GI,and Dmax/Dmean for the bilateral lenses and brainstem compared to the 3DCRT group(all P＜0.05),while their target volume Dmean and CI were higher(P＜0.05).The Hyperarc group had fewer monitor units and a shorter beam-on time than the VMAT and IMRT groups,but higher than the 3DCRT group(all P＜0.05).Conclusion In the radiotherapy of multiple brain metastases,Hyperarc technology demonstrates advantages in target volume dosimetric distribution and organ-at-risk protection.关键词
脑转移瘤/超弧刀/容积调强弧形治疗/调强放射治疗/三维适形放射治疗/剂量学Key words
Brain metastases/Hyperarc/Volume modulation arc therapy/Intensity modulated radiation therapy/Three-dimensional conformal radiotherapy therapy/Dosimetry分类
临床医学
