工业微生物2025，Vol.55Issue(1)：74-77,4.DOI:10.3969/j.issn.1001-6678.2025.01.023
非载药聚乳酸-羟基乙酸共聚物降解特性研究
Study on the Degradation Characteristics of Non-Drug-Loaded Poly(lactic-co-glycolic acid)
初洪珍 1张亚楠 2戚盼 2赵云丽3
作者信息
- 1. 沈阳药科大学药学院,辽宁沈阳 117004||长春金赛药业有限责任公司,吉林长春 130000
- 2. 长春金赛药业有限责任公司,吉林长春 130000
- 3. 沈阳药科大学药学院,辽宁沈阳 117004
- 折叠
摘要
Abstract
The paper took the blank PLGA microsphere as a model to explore the slow-release mechanism of PLGA microspheres,so as to select the in-vitro release method that reflecting the release behavior in-vivo.The gel permeation chromatography(GPC)method was established to determine the molecular weight of the blank PLGA microspheres and verify their effectiveness.The dynamic changes of blank microspheres during the degradation process were studied by in vitro degradation,and the degradation characteristics were investigated by auxiliary characterization means,such as the differential scanning calorimeter(DSC)and the scanning electron microscope(SEM).In this paper,the release conditions of blank PLGA and similar degradation cycles in-vivo were investigated,which can shorten the screening cycle of excipients,and provide the scientific basis for the study of in-vitro release of drug-loaded microspheres.关键词
生物可降解材料/缓释微球/聚乳酸-羟基乙酸共聚物Key words
biodegradable material/sustained release microsphere/PLGA引用本文复制引用
初洪珍,张亚楠,戚盼,赵云丽..非载药聚乳酸-羟基乙酸共聚物降解特性研究[J].工业微生物,2025,55(1):74-77,4.
