工业微生物2025，Vol.55Issue(1)：208-211,4.DOI:10.3969/j.issn.1001-6678.2025.01.052
ICP-MS法测定盐酸雷尼替丁胶囊空胶囊中二氧化钛含量的不确定度评定
Evaluation of Uncertainty in Determination of Titanium Dioxide Content in Ranitidine Hydrochloride Hollow Capsules by ICP-MS
刘轶 1李昭 1李琦 1兰文 1盛忻 2石笑弋1
作者信息
- 1. 湖南省药品检验检测研究院,湖南长沙 410001||国家药品监督管理局药用辅料工程技术研究重点实验室,湖南长沙 410001||湖南省药品质量评价工程技术研究中心,湖南长沙 410001
- 2. 湖南省药品检验检测研究院,湖南长沙 410001
- 折叠
摘要
Abstract
The uncertainty of titanium dioxide content in ranitidine hydrochloride hollow capsules was evaluated by inductively coupled plasma-mass spectrometry(ICP-MS).Meanwhile,according to the requirements and methods of Guidelines for the Evaluation of Uncertainty in Chemical Analysis and Evaluation and Expression of Uncertainty in Measurement,a mathematical model was built to detect the uncertainty in the determination of titanium dioxide content in hollow capsules,aiming at finding out the reasons for the uncertainty,calculating the components of the uncertainty and combining them.The conclusion showed that when the determination result of titanium dioxide in hollow capsules was 9.225 9 g/kg,the expanded uncertainty is 0.260 8 g/kg,k=2.The main cause of uncertainty is the preparation of standard solution.关键词
空胶囊/电感耦合等离子体质谱法/二氧化钛/不确定度Key words
hollow capsule/ICP-MS/titanium dioxide(TiO2)/uncertainty引用本文复制引用
刘轶,李昭,李琦,兰文,盛忻,石笑弋..ICP-MS法测定盐酸雷尼替丁胶囊空胶囊中二氧化钛含量的不确定度评定[J].工业微生物,2025,55(1):208-211,4.
