海南医科大学学报2025，Vol.31Issue(5)：393-400,8.DOI:10.13210/j.cnki.jhmu.20241204.001
LncRNA参与NF-κB信号通路在骨关节炎中的研究进展
Research progress on the involvement of lncRNA in the NF-κB signaling pathway in osteoarthritis
摘要
Abstract
Osteoarthritis(OA)is a chronic disease associated with cartilage degradation,osteophyte formation,and synovial inflammation.Long non-coding RNAs(lncRNAs)are broadly defined as non-coding RNA molecules longer than 200 nucleotides.Emerging research suggests that lncRNAs are involved in the pathogenesis of inflammatory diseases,autoimmune diseases,can-cer,and other conditions,particularly playing significant roles in the pathological processes of cartilage cell differentiation,prolifer-ation,damage,and inflammatory responses in osteoarthritis.Nuclear factor kappa B(NF-κB)is a transcription factor responsible for a variety of biological functions such as inflammation,differentiation,proliferation and survival of cells in vivo,and NF-κB ex-acerbates OA by bridging bone homeostasis and cellular inflammation.In recent years,researchers have found that lncRNAs can affect the onset and progression of OA by regulating the NF-κB pathway.This review summarizes the pathways through which dif-ferent lncRNAs will participate in the NF-κB pathway and thus affect OA,and also explores the significance of lncRNA promotion of the NF-κB pathway in OA,aiming to provide a clearer understanding of the molecular mechanisms of OA as well as new ideas for OA research,and reveal possible potential targets for future therapies.关键词
LncRNA/NF-κB信号通路/骨关节炎Key words
LncRNA/NF-κB/Osteoarthritis(OA)分类
临床医学引用本文复制引用
杨城阔,周塏,杜秀藩,王广积..LncRNA参与NF-κB信号通路在骨关节炎中的研究进展[J].海南医科大学学报,2025,31(5):393-400,8.基金项目
This study was supported by the National Natural Science Foundation of China General Program(2021MSXM10) 国家自然科学基金培育530工程-面上项目(2021MSXM10) （2021MSXM10）
