湖北民族大学学报（自然科学版）2025，Vol.43Issue(1)：25-33,9.DOI:10.13501/j.cnki.42-1908/n.2025.03.002
山桐子油抗氧化活性及其对HepG2非酒精性脂肪性肝病脂质蓄积的影响研究
Study on the Antioxidant Activity of Idesia polycarpa Maxim.Oil and Its Effect on Lipid Accumulation in HepG2 Nonalcoholic Fatty Liver Disease
摘要
Abstract
In order to improve application value of Idesia polycarpa Maxim.oil,based on investigating the antioxidant activity of Idesia polycarpa Maxim.oil,oleic acid(OA)was used to induce human hepatocellular carcinoma(HepG2)cells to establish an in vitro high-fat nonalcoholic fatty liver disease(NAFLD)model,and effects of Idesia polycarpa Maxim.oils on lipid accumulation in the NAFLD model of HepG2 cells were carried out.The results showed that cold-pressed Idesia polycarpa Maxim.oil showed its strong antioxidant capacity,and had a significant effect on the size and number of lipid droplets in NAFLD model of HepG2 cells and the degree of cellular damage.The contents of triglyceride(TG)and total cholesterol(TC),the activities of aspartate transaminase(AST)and alanine transaminase(ALT)in the treated HepG2 cells were significantly decreased.Idesia polycarpa Maxim.oil had a significant mitigating effect on OA-induced fatty degeneration of liver in HepG2 cells by enhancing antioxidant activity,reducing liver injury,and regulating lipid metabolism.The results provided a scientific basis for the development and utilization of as a functional lipid.关键词
山桐子油/抗氧化/肝损伤/脂肪变性/脂质代谢/脂质蓄积Key words
Idesia polycarpa Maxim.oil/antioxidant/liver injury/lipoatrophy/lipid metabolism/lipid accumulation分类
轻工业引用本文复制引用
何华汉,张诗怡,罗凯..山桐子油抗氧化活性及其对HepG2非酒精性脂肪性肝病脂质蓄积的影响研究[J].湖北民族大学学报（自然科学版）,2025,43(1):25-33,9.基金项目
湖北省自然科学基金项目(2023AFD080) （2023AFD080）
硒食品营养与健康智能技术湖北省工程研究中心开放基金项目(PTO82301) （PTO82301）
湖北民族大学研究生教育创新项目(MYK2024074). （MYK2024074）
