河北中医药学报2025，Vol.40Issue(1)：19-25,7.
自拟活血消肿方减轻高能量胫骨平台骨折术前肢体肿胀的临床研究
Clinical Study on Self-prepared Huoxue Xiaozhong Decoction in Alleviating Preoperative Limb Swelling of High-energy Tibial Plateau Fractures
摘要
Abstract
Objective:To explore the application value of self-prepared Huoxue Xiaozhong Decoction in the preoperative prepara-tion stage of high-energy tibial plateau fractures.Methods:This study included 80 patients with high-energy tibial plateau fractures,who were randomly divided into a control group and an observation group,with 40 cases in each group.Both groups received routine swelling reduction treatment,and the observation group was additionally given self-prepared Huoxue Xiaozhong Decoction in addition.The pain control,inflammatory factor levels,treatment progress,swelling reduction,and postoperative joint function of the two groups of patients were evaluated.Results:At 3,5,and 7 days after treatment,the visual analogue scale(VAS)scores for pain in the observation group were lower than those in the control group(P<0.05).At 7 days after treatment,the levels of substance P(SP),prostaglandin E2(PGE2),and neuropeptide Y(NPY)were lower than those in the control group(P<0.05).At 7 days after treatment,the inflammatory indicators C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor(TNF-α)were lower than those in the control group(P<0.05).In the treatment progress,the observation group was superior to the control group in preoperative waiting time,postop-erative hospital stay,and fracture healing time(P<0.05).Regarding swelling indicators,the swelling values of the observation group at 3,5,and 7 days after treatment were better than those of the control group(P<0.05),and the swelling grades at 5 days and 7 days after treatment were also better than those of the control group(P<0.05).At 6 months after surgery,the Hospital for Special Surgery(HSS)knee score of the observation group was higher than that of the control group(P<0.05).The excellent rates of swelling at 3,5,and 7 days after treatment and the excellent rate of HSS at 6 months after surgery in the observation group were all better than those in the control group(P<0.05).Receiver operating characteristic(ROC)curve analysis showed that the excellent rates of swelling and the ex-cellent rate of HSS score at 6 months after surgery in the observation group were AUC=0.613 and AUC=0.600,respectively.Conclusion:The self-prepared Huoxue Xiaozhong Decoction can effectively reduce swelling,alleviate pain,promote the re-covery of postoperative joint function of patients with high-energy tibial plateau fractures during the preoperative preparation stage.关键词
高能量损伤/胫骨平台骨折/自拟活血消肿方/消肿/疼痛控制/关节功能康复Key words
High-energy injury/tibial Plateau fracture/self-prepared Huoxue Xiaozhong Decoction/swelling reduction/pain control/joint function rehabilitation分类
医药卫生引用本文复制引用
邵加龙,要少飞,钟世荣,薛锦标,汤继磊..自拟活血消肿方减轻高能量胫骨平台骨折术前肢体肿胀的临床研究[J].河北中医药学报,2025,40(1):19-25,7.基金项目
南通市中医医疗联盟课题(TZYK202223) （TZYK202223）
