中国实用神经疾病杂志2025，Vol.28Issue(4)：415-420,6.DOI:10.12083/SYSJ.240417
血清CGRP和sIL-2R水平与脑出血患者术后颅内感染的相关性及预测列线图模型的构建
Correlation of serum CGRP and sIL-2R levels with intracranial infection after intracerebral hemorrhage and construction of prediction Nomogram model
摘要
Abstract
Objective To investigate the correlation between serum levels of calcitonin gene-related peptide(CGRP),soluble leukocyte 2 receptor(sIL-2R)and postoperative intracranial infection in patients with cerebral hemorrhage,and to construct a risk profile model for predicting postoperative intracranial infection in patients with cerebral hemorrhage based on CGRP and sIL-2R levels.Methods A total of 168 patients with cerebral hemorrhage were included,all of whom were treated in the First Affiliated Hospital of Nanjing Medical University from October 2020 to October 2023.All subjects underwent craniotomy hematoma removal and were divided into infection group and non-infection group according to whether intracranial infection occurred after operation.Serum CGRP and sIL-2R levels were detected after operation,and clinical data of subjects were collected.Logistic regression was used to analyze the correlation between the levels of serum CGRP,sIL-2R and intracranial infection in patients with cerebral hemorrhage.R 3.6.3 software was used to draw a Nomogram model for predicting the risk of intracranial infection after intracerebral hemorrhage,and the constructed model was verified.Results The acute physiology and chronic health evaluationⅡ(APACHEⅡ)score,sequential organ failure assessment(SOFA)score,procalcitonin(PCT),neutrophil to lymphocyte ratio(NLR),the levels of CGRP and sIL-2R in the infection group were higher than those in the non-infection group(P<0.05).Logistic regression results showed that APACHEⅡ≥17 points,SOFA≥9 points,PCT≥3.12 ng/L,NLR≥4.02,CGRP≥74.58 μg/L,sIL-2R≥248.67 U/mL were risk factors for intracranial infection in patients with intracerebral hemorrhage(P<0.05).The Calibration curve showed good consistency in predicting the risk of intracranial infection in patients with intracerebral hemorrhage(χ2=3.623,P=0.782).The Calibration curve was close to the ideal curve.The C-index of the Nomogram prediction model was 0.816(95%CI:0.796-0.947),and the area under the curve(AUC),95%CI,sensitivity and specificity was 0.841,0.649-0.957,93.60%and 76.50%,respectively(P<0.001).Conclusion The Nomogram model constructed in this study integrates six risk factors,including serum CGRP and sIL-2R,APACHEⅡ score,SOFA score,PCT,and NLR,which has a high predictive value for the risk of postoperative intracranial infection,and could provide a reference for clinicians to make personalized treatment plans.关键词
脑出血/降钙素基因相关肽/可溶性白细胞2受体/血清/颅内感染/危险因素/预测模型Key words
Cerebral hemorrhage/Calcitonin gene-related peptide/Soluble leukocyte 2 receptor/Serum/Intracranial infection/Risk factors/Prediction model分类
医药卫生引用本文复制引用
陆海洋,戴荣兄,吕梦婷..血清CGRP和sIL-2R水平与脑出血患者术后颅内感染的相关性及预测列线图模型的构建[J].中国实用神经疾病杂志,2025,28(4):415-420,6.基金项目
国家自然科学基金资助项目(编号:81900529) （编号:81900529）
