疾病监测与控制2024，Vol.18Issue(5)：337-340,352,5.DOI:10.19891/j.issn1673-9388.(2024)05-0337-05
万古霉素骨水泥联合灌洗引流对感染性骨缺损患者血清炎症指标的影响
EFFECT OF VANCOMYCIN BONE CEMENT ON SERUM INFLAMMATORY MARKERS IN PATIENTS WITH INFECTIOUS BONE DEFECTS
王晨 1张永发 1陈品华1
作者信息
- 1. 福州大学附属省立医院 急诊外科,福建 福州 350001
- 折叠
摘要
Abstract
Objective Exploring the effect of using vancomycin bone cement combined with lavage and drainage on patients with infectious bone defects and its impact on serum inflammatory indicators.Methods Seventy patients with infec-tious bone defects admitted to Fujian Provincial Hospital were selected and included from January 2020 to January 2023.They were divided into a control group of 40 patients who received routine antibiotic irrigation and drainage treatment according to different treatment methods,and an observation group of 30 patients who received treatment with vancomycin bone cement combined with irrigation and drainage.The hospitalization time,bone healing time,serum inflammatory indicators,pain condi-tion[VAS score],and complications were observed in both groups.Results Compared with the control group,the observation group had significantly shorter hospitalization time and bone healing time,and the difference was statistically significant(P＜0.05);Compared with the control group,the observation group had significantly lower levels of procalcitonin(PCT),erythrocyte sedi-mentation rate(ESR),C-reactive protein(CRP),and white blood cell count(WBC)after treatment,with statistical significance(P＜0.05);Compared with the control group,the VAS scores of the observation group were significantly lower after 1 and 2 months of treatment,and the difference was statistically significant(P＜0.05);There was no statistically significant difference in the incidence of complications between the two groups(P＞0.05).Conclusions The use of vancomycin bone cement com-bined with irrigation and drainage can effectively shorten the hospitalization time and bone healing time of patients with infec-tious bone defects,reduce their serum inflammatory index levels,effectively alleviate pain and control infection,and reduce the occurrence of complications.关键词
感染性骨缺损/万古霉素骨水泥/血清炎症/骨愈合Key words
infectious bone defects/vancomycin bone cement/serum inflammation/bone healing分类
医药卫生引用本文复制引用
王晨,张永发,陈品华..万古霉素骨水泥联合灌洗引流对感染性骨缺损患者血清炎症指标的影响[J].疾病监测与控制,2024,18(5):337-340,352,5.
