集成技术2025，Vol.14Issue(2)：86-108,23.DOI:10.12146/j.issn.2095-3135.20231206002
壳聚糖:一种应用在三维骨组织工程中的生物活性支架材料
Chitosan:A Scaffold Biomaterial in 3D Bone Tissue Engineering and Its Biological Activities
摘要
Abstract
The ability to replicate the microenvironment of the human body through the fabrication of scaffolds is a significant achievement in the biomedical field.However,the search for the ideal scaffold is still in its infancy and there are significant challenges to overcome.In the modern era,the scientific community is increasingly turned to natural substances due to their superior biological ability,lower cost,biodegradability,and lower toxicity than synthetic lab-made products.Chitosan is a well-known polysaccharide that has recently garnered a high amount of attention for its biological activities,especially in 3D bone tissue engineering.Chitosan closely matches the native tissues and thus stands out as a popular candidate for bioprinting.This review focuses on the potential of chitosan-based scaffolds for advancements and the drawbacks in bone treatment.Chitosan-based nanocomposites have exhibited strong mechanical strength,water-trapping ability,cellular interaction,and biodegradability.Chitosan derivatives have also encouraged and provided different routes for treatment and enhanced biological activities.3D tailored bioprinting has opened new doors for designing and manufacturing scaffolds with biological,mechanical,and topographical properties.关键词
壳聚糖/3D生物打印/骨组织工程/支架/组织再生/壳聚糖衍生物Key words
chitosan/3D bioprinting/bone tissue engineering/scaffold/tissue regeneration/chitosan derivative分类
生物学引用本文复制引用
Gurung Chetali,Nawaz Aamir,Udduttulla Anjaneyulu,任培根..壳聚糖:一种应用在三维骨组织工程中的生物活性支架材料[J].集成技术,2025,14(2):86-108,23.基金项目
国家重点研发计划项目(2021YFA0719303) （2021YFA0719303）
国家自然科学基金项目(32271166,32100572) （32271166,32100572）
广东省基础与应用基础研究基金项目(2024A1515013017) （2024A1515013017）
深圳市科技计划项目(JCYJ20200109115441918,KCXFZ2020122113400002,JCYJ20210324102013035,JCYJ20210324123610028) This work was supported by National Key Research and Development Program of China(2021YFA0719303),National Natural Science Foundation of China(32271166,32100572),Guangdong Basic and Applied Basic Research Foundation(2024A1515013017),Shenzhen Science and Technology Program(JCYJ20200109115441918,KCXFZ2020122113400002,JCYJ20210324102013035,JCYJ20210324123610028) （JCYJ20200109115441918,KCXFZ2020122113400002,JCYJ20210324102013035,JCYJ20210324123610028）
