解放军医学杂志2025，Vol.50Issue(2)：154-161,8.DOI:10.11855/j.issn.0577-7402.1631.2024.0708
18F标记成纤维细胞活化蛋白抑制剂PET/CT对18F-FDG摄取偏低恶性肿瘤的临床诊断价值
Clinical diagnosis value of 18F-fibroblast-activation protein inhibitor PET/CT in malignant tumors with low 18F-fluorodeoxyglucose uptake
梁志盈 1林培颖 1张汝森 1李雯 1李伟1
作者信息
- 1. 广州医科大学附属肿瘤医院核医学科,广东 广州 510095
- 折叠
摘要
Abstract
Objective To evaluate the clinical value of 18F-fibroblast-activation protein inhibitor(18F-FAPI)PET/CT in malignant tumors exhibiting low uptake of 18F-fluorodeoxyglucose(18F-FDG).Methods We prospectively analyzed 62 patients with malignant tumors and low 18F-FDG uptake who underwent 18F-FAPI PET/CT in the Affiliated Cancer Hospital and Institute of Guangzhou Medical University from January 2021 to November 2022.Patient demographics information,clinical and radiological data were collected.Tumor lesions were categorized based on 18F-FAPI and 18F-FDG uptake relative to surrounding tissues into low-,moderate-,and high-uptake,with high uptake indicating positivity.The number and tracer uptake levels of primary tumors and metastatic lesions visualized by both 18F-FDG and 18F-FAPI were recorded and compared.Results Of the 62 primary tumors,18(29.0%)showed low-uptake and 44(71.0%)moderate-uptake on 18F-FDG PET,while 1(1.6%),6(9.7%),and 55(88.7%)showed low,moderate,and high uptake on 18F-FAPI,respectively.The maximum standardized uptake value(SUVmax)for primary tumors was significantly higher with 18F-FAPI than with 18F-FDG(7.5±5.6 vs.3.9±2.1,P<0.01).The number of positive lymph node foci revealed by 18F-FAPI was noticeably higher than that by 18F-FDG(77 vs.38,P<0.01).A total of 16 distant organ metastases were identified,with 11(68.8%)detected by 18F-FDG and 15(93.8%)by 18F-FAPI,showing no significant difference in detection rates(P>0.05).Conclusions 18F-FAPI PET/CT effectively visualizes primary and metastatic lesions in malignant tumors with low 18F-FDG uptake,suggesting its potential as a promising radiotracer for such malignancies.关键词
18F标记的成纤维细胞活化蛋白抑制剂/18F-氟代脱氧葡萄糖/PET/CT/肿瘤/低摄取Key words
18F-fibroblast-activation protein inhibitors/18F-fluorodeoxyglucose/PET/CT/neoplasm/non-avidity分类
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梁志盈,林培颖,张汝森,李雯,李伟..18F标记成纤维细胞活化蛋白抑制剂PET/CT对18F-FDG摄取偏低恶性肿瘤的临床诊断价值[J].解放军医学杂志,2025,50(2):154-161,8.
