解放军医学杂志2025，Vol.50Issue(2)：221-231,11.DOI:10.11855/j.issn.0577-7402.1503.2024.0529
泛凋亡的分子机制及其在部分疾病中的作用研究进展
Research progress on the molecular mechanisms of PANoptosis and its role in some diseases
摘要
Abstract
Cellular death in the body can occur through different processes,including apoptosis,pyroptosis and necrotic apoptosis,etc.PANoptosis is a newly discovered form of inflammatory cell death in recent years.It can be triggered by various stimulating factors and integrates multiple components that can induce cell death to assemble into various types of macromolecular complexes-PANoptosome,which then mediates cell death.Given the impact of PANoptosis on the entire disease spectrum,promoting or inhibiting its occurrence process may prevent the development of various diseases.The review summarizes the research progress on the occurrence mechanism of PANoptosis and its role in some diseases,and explores the crosstalk among multiple programmed cell death pathways,aiming to provide new ideas for the treatment of related diseases.关键词
泛凋亡/细胞死亡/疾病/分子机制Key words
PANoptosis/cell death/illness/molecular mechanism分类
基础医学引用本文复制引用
宋宇琪,杨文明,魏涛华,杨玉龙,李子龙..泛凋亡的分子机制及其在部分疾病中的作用研究进展[J].解放军医学杂志,2025,50(2):221-231,11.基金项目
This work was supported by the National Natural Science Foundation of China(81973825,82305185,U22A20366),and the Science Foundation of Anhui Province(2108085QH367) 国家自然科学基金(81973825,82305185,U22A20366) （81973825,82305185,U22A20366）
安徽省自然科学基金(2108085QH367) （2108085QH367）
