激光生物学报2025，Vol.34Issue(1)：26-35,10.DOI:10.3969/j.issn.1007-7146.2025.01.004
激光散斑衬比成像监测大鼠植皮术后的血流变化
Laser Speckle Contrast Imaging for Monitoring Blood Flow Changes after Skin Grafting of Rats
摘要
Abstract
To investigate the influence of deep and superficial blood supply of skin tissue on post-grafting recovery,rat models of deep ischemic skin and multifactorial rat models of superficial skin were constructed in study.Laser speckle contrast imaging technique was utilized to monitor the skin perfusion status.In the models,the relative blood perfusion index was measured and quantified in the skin grafting area by controlling the blood supply in different regions,while the tissue perfusion ratio was analyzed to assess postoperative skin recovery trends.The results indicated that in the rat model of deep ischemic skin,the tissue perfusion ratio of the femoral artery ligature group was lower than that of the normal group.In the multifactorial rat model of superficial skin,the experimental groups subjected to ischemia and cauterization showed lower blood perfusion ratios compared to the control group.By establishing two animal models in study,it was demonstrated that the laser speckle contrast imaging technique can provide real-time monitoring of blood flow after grafting surgery.The blood supply to both deep and superficial skin tissues directly affects the postoperative recovery of the area.关键词
激光散斑衬比成像/皮肤移植/血供/血流灌注/大鼠Key words
laser speckle contrast imaging/skin graft/blood supply/blood perfusion/rats分类
基础医学引用本文复制引用
曹梦,李玥,高攀,李一鸣,杨晖..激光散斑衬比成像监测大鼠植皮术后的血流变化[J].激光生物学报,2025,34(1):26-35,10.基金项目
国家自然科学基金项目(12072200,12372384). （12072200,12372384）
