摘要
Abstract
Objective To investigate the effect of admission glucose and fibrinogen ratio(AGFR)and mean arterial pressure(MAP)on prognosis of patients with acute hemorrhagic stroke.Methods The clinical data of 145 patients with acute hemor-rhagic stroke in the Hubei third People's Hospital from May 2020 to May 2023 were retrospectively analyzed.According to the prognosis,111 patients were divided into the improved group and 34 patients were non-cured groupe.The general data of the two groups of patients were compared,the proportion of disease improvement rate of AGFR with different values was analyzed,and the relationship between AGFR,MAP and combined prediction model and clinical prognosis of patients with hemorrhagic stroke was explored.Results Patients with AGFR＜1 had a recovery rate of 84.5％and those with AGFR＞1 had a recovery rate of 31.8％.There were significant differences in smoking history,hypertension history,coronary heart disease history,complications,blood sodium,AGFR,MAP,platelet,Glasgow coma score(GCS)between the improved group and the non-cured group(P＜0.05).Logistic multiple regression analysis showed that AGFR,MAP(β=1.699,OR=5.466,95％CI:1.789-16.701),GCS scores(β=-0.159,OR=0.853,95％CI:0.744-0.978),platelet(β=-0.010,OR=0.990,95％CI:0.982-0.999),smoking history(β=-1.222,OR=0.295,95％CI:0.088-0.991)and history of coronary heart disease(β=-1.619,OR=0.198,95％CI:0.054-0.721)were independent risk factors for poor prognosis in patients with acute hem-orrhagic stroke(P＜0.05).Receiver operating characteristic(ROC)analysis showed that the combined prediction AUC was 0.781 5,95％CI:0.730-0.834(P＜0.05),Yoden index was 0.445,sensitivity was 60.4％,and specificity was 84.0％.Deci-sion curve analysis(DCA)showed that the combined prediction model had high clinical predictive value when the risk threshold was 0.28-0.39.Conclusion The AGFR can predict the prognosis of patients with acute hemorrhagic stroke.The combined prediction model of MAP and AGFR can predict the deterioration of acute hemorrhagic stroke patients.Factors such as GCS score,platelet content,smoking history,and history of coronary heart disease provided additional risk sharing information for hemorrhagic stroke prognosis.关键词
出血性脑卒中/入院血糖与纤维蛋白原比值/平均动脉压/危险因素/预后Key words
Haemorrhagic stroke/Admission glucose to fibrinogen ratio/Mean arterial pressure/Risk factors/Prognosis分类
医药卫生
