中国当代医药2025，Vol.32Issue(5)：17-22,28,7.DOI:10.3969/j.issn.1674-4721.2025.05.04
三阴性乳腺癌根治术患者术前炎症相关指标与预后的相关性
Correlation between preoperative inflammation-related indicators and prognosis in triple-negative breast cancer patients undergoing radical mastectomy
摘要
Abstract
Objective To investigate the predictive value of preoperative related inflammatory indicators for survival prognosis of patients with triple negative breast cancer(TNBC).Methods A total of 280 patients with TNBC who underwent radical mastectomy in Heze Municipal Hospital from January 2018 to May 2020 were selected as the research objects.Clinical baseline characteristics and preoperative inflammation-related indicators,including systemic immune inflammation index(SII)level,neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR)and lymphocyte/monocyte ratio(LMR)were col-lected.Univariate Cox analysis was performed on clinical baseline characteristics.The critical values for the above inflammation-related indicators were determined using receiver operating characteristic curve analysis.Survival curves were plotted using the Kaplan-Meier method,and survival analysis was conducted using Log-rank test.Multivariate analysis was used to evaluate the prognostic value of related factors.Re-sults The median survival rate of 280 patients was 34.09 months.Univariate Cox analysis showed that age,tumor stage,tu-mor maximum diameter,lymph node metastasis,and chemotherapy were the prognostic factors of TNBC patients(P＜0.05).There were different diagnostic values for postoperative recurrence and metastasis of breast cancer by different inflammatory markers.The cut-off values of preoperative inflammatory indicators were SII=546.86,NLR=2.27,PLR=128.54,LMR=5.20.Tumor stage Ⅱ(β=1.131,OR=3.099,95％CI:1.308-7.345),tumor stage Ⅲ(β=1.836,OR=6.269,95％CI:2.778-14.149),tumor maximum diameter 2～5 cm(β=0.808,OR=2.243,95％CI:1.146-4.388),tumor maximum diameter＞5 cm(β=1.308,OR=2.765,95％CI:1.864-7.342),lymph node metastasis(β=1.017,OR=2.765,95％CI:1.537-4.975),PLR ≥128.54(β=0.449,OR=1.567,95％CI:1.038-2.366)were independent risk factors for disease-free survival of TNBC patients(P＜0.05),L MR≥5.20(β=-0.730,OR=0.482,95％CI:0.292-0.796)was independent protective factor for disease-free survival of TNBC patients(P＜0.05).Conclusion Tumor stage,tumor maximum diameter,lymph node metas-tasis,PLR and LMR can be used as independent prognostic factors for TNBC patients.关键词
三阴型乳腺癌/预后/系统性免疫性炎症/中性粒细胞和淋巴细胞比值/血小板和淋巴细胞比值/淋巴细胞和单核细胞比值Key words
Triple negative breast cancer/Prognosis/Systemic immune inflammation/Neutrophil-lymphocyte ratio/Platelet-lymphocyte ratio/Lymphocyte/monocyte ratio分类
临床医学引用本文复制引用
周阳,刘鹏,付晨瑜,郭腾飞,刘烁..三阴性乳腺癌根治术患者术前炎症相关指标与预后的相关性[J].中国当代医药,2025,32(5):17-22,28,7.基金项目
山东省医药卫生科技发展计划项目(202102081098). （202102081098）
