摘要
Abstract
Objective To investigate the clinical effect of Finelidone combined with Beprost Sodium in the treatment of dia-betic nephropathy(DN).Methods A total of 86 patients with DN in Puning Overseas Chinese Hospital from January 2023 to January 2024 were selected as the study objects and they were divided into control group and observation group by random number table method,with 43 cases in each group.The control group was treated with Beprost Sodium,and the observation group was treated with Finelidone Tablets combined with Beprost Sodium.Both groups were treated for 3 months.The clinical effect,symptom improvement,renal function index and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statisti-cally significant(P＜0.05).The improvement time of limb edema,proteinuria,pallor and fatigue in the observation group were shorter than those in the control group,the differences were statistically significant(P＜0.05).Urinary albumin creati-nine(UACR),urinary albumin excretion(UAE),24 h urinary protein quantification(24-UP)and serum creatinine(SCr)in observation group were lower than those in control group,and glomerular filtration rate(GFR)was higher than that in control group,the differences were statistically significant(P＜0.05).The levels of fasting plasma glucose(FPG),2 h postprandial plasma glucose(2 h PG)and glycosylated hemoglobin(HbA1c)in observation group were lower than those in control group,with statistical significances(P＜0.05).There was no significant difference in the total incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion Finelidone combined with Beprost Sodium can alleviate the symptoms of DN patients,improve renal function and blood glucose indexes,and have no obvious adverse reactions.关键词
糖尿病肾病/非奈利酮/贝前列素钠/肾功能/血糖Key words
Diabetic nephropathy/Feneridone/Beprost Sodium/Renal function/Blood glucose分类
医药卫生
