刘欣 1刘力 2赵雅 1曾晓琴 1刘香玉 3夏瑞1
作者信息
- 1. 长江大学附属第一医院(荆州市第一人民医院)麻醉科,湖北荆州 434000
- 2. 山东财经大学统计与数学学院,山东济南 250000
- 3. 山东第一医科大学附属省立医院(山东省立医院)麻醉科,山东济南 250000
- 折叠
摘要
Abstract
Objective To investigate the efficacy and safety of Ciprofol combined with Remimazolam Tosilate in painless gastroenteroscopy.Methods A total of 120 patients who underwent painless gastroenteroscopy from April to June 2023 were selected as the study objects,and the patients were divided into Ciprofol group(group C),Remimazolam group(group R)and Ciprofol combined with Remimazolam group(group CR)by random number table method,with 40 cases in each group.After 5 μg/kg of Alfentanil was administered to all three groups,group C was given Ciprofol 0.5 mg/kg intravenously,group R was given Remimazolam Tosilate 0.3 mg/kg intravenously,and group CR was given Ciprofol 0.25 mg/kg intravenously followed by Remimazolam Tosilate 0.1 mg/kg intravenously.The success rate of sedation,times of drug addition and recovery time of the three groups were compared.Heart rate(HR),oxygen saturation(SpO2),respiratory rate(RR),bifrequency index(BIS)and mean arterial pressure(MAP)were recorded before induction of anesthesia(T1),when gastroscopy was passed through throat(T2),at the beginning of colonoscopy(T3),when colonoscopy was passed through liver curvature(T4),and at the end of examination(15).1 he incidence of adverse events such as perioperative hypoxemia,circulation inhibition,hiccup,cough and body movement were compared.Results The recovery time of group CR was shorter than that of group C,the difference was statistically significant(P＜0.05).At T2,SpO2 of group CR was higher than that of group C,BIS value was lower than that of group C,and HR was lower than that of group R,SpO2 in group CR was higher than that in group C at T3-T5,At T3 and T4,the BIS value of group CR were lower than those of group R.At T5,the BIS value of group CR was higher than that of group C,the differences were statistically significant(P＜0.05).There were no statistical significances in the in-cidence of hypoxemia,circulatory depression and cough among the three groups(P＞0.05).The incidence of hiccup in group C was lower than that in group R,and the incidence of body movement in group CR was lower than that in group R,with statistical significance(P＜0.017).Conclusion The combination of Ciprofol and Remimazolam Tosilate has a better sedative effect,with less respiratory impact on patients,shorter awakening time,higher awakening quality,lower incidence of adverse events such as hiccup and body movement,and can be safely,effectively and comfortably applied in painless gastrointestinal endoscopy.关键词
环泊酚/甲苯磺酸瑞马唑仑/无痛胃肠镜/脑电双频指数/呃逆Key words
Ciprofol/Remimazolam Tosilate/Painless gastrointestinal endoscope/Bispectral index/Hiccup分类
医药卫生
