基于网络药理学和分子对接技术探讨参苓白术散"异病同治"慢性阻塞性肺疾病与糖尿病的作用机制OA
Mechanism of"treating different diseases with the same method"for chronic obstructive pulmonary disease and diabetes with Shenling Baizhu San based on network pharmacology and molecular docking
目的 基于网络药理学和分子对接技术探讨参苓白术散"异病同治"慢性阻塞性肺疾病(COPD)与糖尿病(DM)的作用机制.方法 检索综合数据库,收集参苓白术散的活性成分及其靶点,并进行标准化处理;从人类基因数据库(GeneCards)、在线人类孟德尔遗传数据库(OMIM)等数据平台收集COPD和DM的相关靶点.利用Evenn软件确定药物与疾病的交集靶点,将其导入STRING数据库构建蛋白质相互作用(PPI)网络,并应用Cytoscape软件进行可视化分…查看全部>>
Objective To explore the mechanisms of"treating different diseases with the same method"for chronic obstructive pulmonary disease(COPD)and diabetes mellitus(DM)with Shen-ling Baizhu San based on network pharmacology and molecular docking.Methods Comprehensive databases were searched to collect the active ingredients and targets of Shenling Baizhu San,which were then performed standardized process.Relevant targets for COPD and DM were collected from data plat…查看全部>>
马静;贾天凤;毛海飞;杨继红
山西医科大学管理学院,山西太原,030600山西医科大学管理学院,山西太原,030600山西中医药大学,山西太原,030600山西中医药大学,山西太原,030600
临床医学
网络药理学异病同治慢性阻塞性肺疾病糖尿病分子对接参苓白术散
network pharmacologytreating different diseases with the same methodchron-ic obstructive pulmonary diseasediabetes mellitusmolecular dockingShenling Baizhu San
《实用临床医药杂志》 2025 (3)
38-45,8
山西省中医药管理局科研项目(2023ZYYA2011)
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