实用临床医药杂志2025，Vol.29Issue(3)：51-56,6.DOI:10.7619/jcmp.20240733
神经调节蛋白4联合γ-氨基丁酸对重度阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍的预测价值
Value of neuregulin 4 combined with γ-aminobutyric acid in predicting cognitive dysfunction among patients with severe obstructive sleep apnea-hypopnea syndrome
摘要
Abstract
Objective To investigate the predictive value of neuregulin 4(Nrg4)combined withγ-aminobutyric acid(GABA)in cognitive dysfunction among patients with severe obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 169 patients with severe OSAHS were se-lected as study subjects and divided into normal cognitive function group(n=89)and cognitive dys-function group(n=80)based on cognitive function assessment results.General information of the pa-tients was collected,and the levels of Nrg4 and GABA were detected by enzyme-linked immunosor-bent assay(ELISA).Receiver operating characteristic(ROC)curve analysis was used to evaluate the predictive value of Nrg4 and GABA for cognitive dysfunction in OSAHS patients.Results The proportions of patients with a history of hypertension and diabetes,as well as the levels of diastolic blood pressure,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were significantly higher in the cognitive dysfunction group than those in the normal cognitive function group(P＜0.05).The levels of Nrg4 and GABA were significantly lower in the cognitive dysfunction group than in the normal cognitive function group(P＜0.05).The Montreal Cognitive Assessment(MoCA)score in the cognitive dys-function group was significantly lower than that in the normal cognitive function group[(12.36±2.35)versus(28.25±1.02),P＜0.05].Multivariate Logistic regression analysis revealed that a history of hypertension and diabetes,diastolic blood pressure,TC,TG,HDL-C,and LDL-C were risk factors for cognitive dysfunction in patients with severe OSAHS(P＜0.05),while Nrg4,GABA,and MoCA scores were protective factors(P＜0.05).ROC curve analysis showed that combined de-tection of Nrg4 and GABA had a higher predictive value for cognitive dysfunction in patients with se-vere OSAHS compared with either marker alone(P＜0.05).Conclusion A history of hyperten-sion and diabetes,diastolic blood pressure,TC,TG,HDL-C,LDL-C,Nrg4,GABA,and MoCA scores are all factors influencing cognitive dysfunction in patients with severe OSAHS.Combined de-tection of Nrg4 and GABA can effectively predict cognitive dysfunction in these patients.关键词
阻塞性睡眠呼吸暂停低通气综合征/认知功能障碍/神经调节蛋白4/γ-氨基丁酸Key words
obstructive sleep apnea-hypopnea syndrome/cognitive dysfunction/neuregulin 4/γ-aminobutyric acid分类
临床医学引用本文复制引用
王晖,肖海燕,陈平,张昊,巩远方,张金洪,张书研,温永飞..神经调节蛋白4联合γ-氨基丁酸对重度阻塞性睡眠呼吸暂停低通气综合征患者认知功能障碍的预测价值[J].实用临床医药杂志,2025,29(3):51-56,6.基金项目
河北省沧州市科技计划自筹经费项目(222106111) （222106111）
