实用临床医药杂志2025，Vol.29Issue(3)：118-122,5.DOI:10.7619/jcmp.20242394
支气管哮喘患儿急性期血清双特异性磷酸酶1、可溶性分化簇93与病情严重程度、肺功能和气道炎症的相关性研究
Correlations of serum dual-specific phosphatase 1 and soluble cluster of differentiation 93 with severity of disease,lung function and airway inflammation in children with acute-phase bronchial asthma
摘要
Abstract
Objective To investigate the correlations of serum dual-specific phosphatase 1(DUSP1)and soluble cluster of differentiation 93(sCD93)with severity of disease,lung function and airway inflammation in children with acute-phase bronchial asthma(BA).Methods A total of 100 children with acute-phase BA(acute-phase group),100 children with remission-phase BA(remis-sion-phase group),and 100 healthy children(control group)in the Xingyuan Hospital of Yulin from January 2021 to January 2023 were selected,and the acute-phase group was further divided into mild subgroup(n=47),moderate subgroup(n=36)and severe subgroup(n=17)according to the se-verity of the disease.Serum DUSP1,sCD93 levels and lung function indexes[peak expiratory flow(PEF),percentage of forced expiratory volume in the first second compared to the expected value(FEV1％pred)],and airway inflammation indexes[eosinophil(EOS)count,fractional exhaled nitric oxide(FeNO)]were measured.Pearson's method was used to analyze the correlations of serum DUSP1 and sCD93 levels with PEF,FEV1％pred,EOS and FeNO in children with acute-phase BA.Results The levels of serum DUSP1,PEF,and FEV1％pred in the acute-phase group were signifi-cantly lower than those in the remission-phase group and the control group,while the levels of sCD93,EOS count and FeNO were significantly higher than those in the remission-phase group and the control group(P＜0.01).The levels of serum DUSP1,PEF and FEV1％pred in the severe subgroup were significantly lower than those in the moderate and mild subgroups,while the levels of sCD93,EOS count and FeNO were significantly higher than those in the moderate and mild sub-groups(P＜0.01).PEF and FEV1％pred were positively correlated with serum DUSP1 level,but negatively correlated with sCD93 level in children with acute-phase BA(P＜0.01).EOS count and FeNO were negatively correlated with serum DUSP1 level,but positively correlated with sCD93 level(P＜0.01).Conclusions The decreased serum DUSP1 level and increased sCD93 level in chil-dren with acute-phase BA are closely related to the aggravation of the disease,the decrease of lung function,and airway inflammation,which may become new targets for the treatment of children with acute-phase BA.关键词
儿童/支气管哮喘/双特异性磷酸酶1/可溶性分化簇93/病情严重程度/肺功能/气道炎症Key words
children/bronchial asthma/dual-specific phosphatase 1/soluble cluster of dif-ferentiation 93/severity of disease/lung function/airway inflammation分类
医药卫生引用本文复制引用
马娇,霍静雨,韩彩云..支气管哮喘患儿急性期血清双特异性磷酸酶1、可溶性分化簇93与病情严重程度、肺功能和气道炎症的相关性研究[J].实用临床医药杂志,2025,29(3):118-122,5.基金项目
陕西省2023年科技计划项目(2023KRM028) （2023KRM028）
