实用临床医药杂志2025，Vol.29Issue(4)：34-37,43,5.DOI:10.7619/jcmp.20243338
糖尿病周围神经病变患者血清调节性T细胞相关因子与疼痛介质的关系
Relationship between serum regulatory T cell-related factors and pain mediators in patients with diabetic peripheral neuropathy
摘要
Abstract
Objective To investigate the dynamic changes of serum regulatory T cell(Treg cell)-related factors in patients with diabetic peripheral neuropathy(DPN)and their relationships with pain mediators.Methods A total of 140 patients with DPN were enrolled and divided into painful DPN group(36 patients)and painless DPN group(104 patients)based on the presence of neuropathic pain.The serum levels of Treg cell-related factors[interleukin-10(IL-10),transforming growth fac-tor-β1(TGF-β1),interleukin-35(IL-35)]and pain mediators[prostaglandin E2(PGE2),hista-mine(His),and 5-hydroxytryptamine(5-HT)]between the two groups were compared.Pearson cor-relation analysis was used to explore the correlations of the serum levels of IL-10,TGF-β1,and IL-35 with the levels of PGE2,His,and 5-HT in patients with DPN.Multiple linear regression analysis was conducted to investigate the influencing factors of pain intensity in patients with DPN.Results The serum levels of TGF-β1,PGE2,His,and 5-HT were higher,while the levels of IL-10 and IL-35 were lower in the painful DPN group than those in the painless DPN group(P＜0.05).Pearson correlation a-nalysis showed that IL-10 was negatively correlated with PGE2,His,and 5-HT(r=-0.781,-0.794,-0.714,P＜0.05);TGF-β1 was positively correlated with PGE2,His,and 5-HT(r=0.605,0.590,0.515,P＜0.05);IL-35 was negatively correlated with PGE2,His,and 5-HT(r=-0.727,-0.847,-0.727,P＜0.05).Multiple linear regression analysis revealed that IL-10,TGF-β1,and IL-35 were closely related to the pain intensity in patients with DPN and were influencing factors of painin-tensity(P＜0.05).Conclusion The serum levels of IL-10 and IL-35 in patients with DPN are negatively correlated with the levels of PGE2,His,and 5-HT,while the level of TGF-β1 is positive-ly correlated with these pain mediators.Furthermore,IL-10,TGF-β1,and IL-35 are closely related to the degree of neuropathic pain in patients with DPN.关键词
糖尿病周围神经病变/调节性T细胞/疼痛介质/神经病理性疼痛Key words
diabetic peripheral neuropathy/regulatory T cells/pain mediators/neuropathic pain分类
医药卫生引用本文复制引用
刘盼梅,樊肖冲,刘青颖,马民玉..糖尿病周围神经病变患者血清调节性T细胞相关因子与疼痛介质的关系[J].实用临床医药杂志,2025,29(4):34-37,43,5.基金项目
国家自然科学基金项目(82001182) （82001182）
河南省医学科技攻关计划(联合共建)项目(LHGJ20190214) （联合共建）
