实用临床医药杂志2025，Vol.29Issue(4)：119-122,128,5.DOI:10.7619/jcmp.20242961
罗哌卡因复合舒芬太尼不同脉冲剂量用于程控硬膜外间歇脉冲注入分娩镇痛的效果研究
Efficacy of different bolus dose of ropivacaine combined with sufentanil for programmed intermittent epidural bolus infusion in labor analgesia
摘要
Abstract
Objective To observe the efficacy of different pulse dose of ropivacaine combined with sufentanil for programmed intermittent epidural bolus(PIEB)infusion in labor analgesia and its impact on maternal and neonatal safety.Methods A total of 300 parturients undergoing labor anal-gesia were randomly divided into group A,group B,and group C,with 100 parturients in each group.The analgesic regimen consisted of 0.08％ropivacaine combined with 0.5 μg/mL sufentanil.The bolus infusion doses for groups A,B,and C were 6 mL,8 mL,and 10 mL,respectively,with a bolus interval of 40 min.The patient-controlled analgesia(PCA)dose was the same as the corre-sponding bolus dose,with a lockout time of 15 min.The medication was discontinued after fetal deliv-ery,with a limit dose of 30 mL/h.The Visual Analogue Scale(VAS)scores before analgesia(T0)and at 30 min(T1),1 h(T2),2 h(T3),3 h(T4)after analgesia,full dilation of the cervix(T5),and immediately after delivery(T6)were compared among groups.Additionally,the inci-dence of breakthrough pain,the first occurrence time of breakthrough pain,the rate of rescue analge-sia,the number of PCA pump presses,delivery outcomes,and neonatal conditions were compared.Results At each time points from T1 to T6,the VAS scores in all three groups were lower than that at T0,and were lower in groups B and C than those in group A(P＜0.05).However,there was no statistically significant difference in VAS scores between groups B and C(P＞0.05).The incidence of breakthrough pain,the rate of rescue analgesia,and the number of PC A pump presses were lower in the groups B and C than those in the group A,and the first occurrence time of breakthrough pain was later in groups B and C than those in group A(P＜0.05).There were no statistically signifi-cant differences among the three groups in neonatal birth weight,1-min and 5-min Apgar scores,neonatal behavioral neurological assessment(NBNA)scores,and the incidence of neonatal asphyxia(P＞0.05).Conclusion 0.08％ropivacaine combined with 0.5 μg/mL sufentanil for PIEB in labor analgesia is safe and effective,with a bolus dose of 8 mL achieving good analgesic effects and having minimal impact on both mothers and neonates.关键词
分娩镇痛/程控硬膜外间歇脉冲注入/罗哌卡因/舒芬太尼Key words
labor analgesia/programmed intermittent epidural bolus infusion/ropivacaine/sufentanil分类
医药卫生引用本文复制引用
祁春华,陈春,徐阳..罗哌卡因复合舒芬太尼不同脉冲剂量用于程控硬膜外间歇脉冲注入分娩镇痛的效果研究[J].实用临床医药杂志,2025,29(4):119-122,128,5.基金项目
白求恩公益基金会恩泽疼痛管理医学研究项目(ezmr2023-016) （ezmr2023-016）
