扬州大学学报（农业与生命科学版）2025，Vol.46Issue(1)：110-120,11.DOI:10.16872/j.cnki.1671-4652.2025.01.013
牡丹籽饼粕提取物生物活性及活性成分分析
Analysis of active ingredients and bioactivities of Paeonia suffruticosa Andr.seed cake extracts
摘要
Abstract
In order to make effective use of Paeonia suffruticosa Andr.(peony)seed meal resources,the antioxidant activities,anticholinesterase activities and antibacterial activities of different extracts of peony seed meal were compared and studied in vitro.The active components of peony seed meal were analyzed by liquid chromatography mass spectrometry(LC-MS),and the active components and potential target proteins were analyzed by molecular docking technology.The results showed that the total phenol contents of 70％methanol extract of peony seed meal was the highest[(159.50±4.29)mg·g-1],and its antioxidant,anticholinesterase and antibacterial activities were the strongest in vitro.LC-MS analysis showed that the main active components of 70％methanol extract of peony seed meal were paeoniflorin,suffruticosol A,suffruticosol B,suffruticosol C and ε-viniferin.Molecular docking results showed that the active components of peony seed meal had good binding ability to various anti-oxidation and anti-aging target proteins,among which ε-viniferin had the strongest binding ability.The results indicated that the 70％methanol extract of peony seed meal had the highest antioxidant,anti-aging and antibacterial activities,which were mainly related to the active components of polyphenols oligostilbene.关键词
牡丹籽饼粕/提取物/抗氧化活性/抗胆碱酯酶活性/抗菌活性Key words
Paeonia suffruticosa Andr.seeds cake/extracts/antioxidant activity/anti-acetylcholinesterase activity/antibacterial activity分类
农业科技引用本文复制引用
陈雨婷,尹佳欣,金银哲,邹逸泓,金萍,陶俊,金英善..牡丹籽饼粕提取物生物活性及活性成分分析[J].扬州大学学报（农业与生命科学版）,2025,46(1):110-120,11.基金项目
国家重点研发计划项目(2019YFD1001502) （2019YFD1001502）
江苏省人兽共患病重点实验室开放课题(R2109) （R2109）
江苏省研究生实践创新基金项目(SJCX21-1598) （SJCX21-1598）
