摘要
Abstract
Objective To investigate the effect of nicotinamide injection combined with bisoprolol on cardiac function and oxidative stress response in patients with acute myocardial infarction(AMI).Methods A retrospective study was conducted on 97 patients with AMI who had undergone percutaneous coronary intervention.These patients were divided into control group(n=47)and combination group(n=50)based on different treatment methods.The control group was treated with bisoprolol,while the combination group was treated with nicotinamide combined with bisoprolol.The two groups were continuously treated for 2 weeks.The clinical efficacy,and total incidence of adverse reactions were compared between the two groups,as well as cardiac function indicators[ejection fraction,cardiac index,left ventricular end-diastolic volume(LEDV)and left ventricular end-systolic volume(LESV)],oxidative stress response indicators[malondialdehyde(MDA)and superoxide dismutase(SOD)],serum indicators[NT-proBNP,cTn I,endothelin and CK-MB]before and after the treatment.Results The total clinical efficacy rate of the combination group was higher than that of the control group(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the cardiac function indicators of ejection fraction,cardiac index,LEDV,and LESV in the combination group were all higher than those in the control group(all P<0.01);the level of the oxidative stress response indicator of MDA was lower than that in the control group,while SOD level was higher(P<0.01).After treatment,the levels of the serum indicators of NT-proBNP,cTn I,endothelin,and CK-MB all reduced in both groups,with greater reduction amplitude in the combination group(P<0.05).Conclusion The treatment regimen of nicotinamide injection combined with bisoprolol for patients with AMI is safe and effective,which could significantly improve cardiac function,reduce oxidative stress response,and alleviate myocardial injury.关键词
烟酰胺/比索洛尔/急性心肌梗死/心功能/氧化应激反应Key words
nicotinamide/bisoprolol/acute myocardial infarction/cardiac function/oxidative stress response分类
医药卫生
