摘要
Abstract
Objective To explore the therapeutic effect of metoprolol combined with clopidogrel on coronary heart disease(CHD)and angina pectoris.Methods A prospective randomized controlled study was performed,and 100 patients with CHD and angina pectoris were selected as research objects.They were divided into clopidogrel group and combined medication group,with 50 cases in each group.Clopidogrel group was treated with clopidogrel,while the combined medication group was treated with metoprolol based on the medication of the clopidogrel group.The distance of 6-minute walk test(6MWT),duration of angina pectoris,cardiac function,adverse drug reactions,and quality of life were compared between the two groups before and after treatment.Results After treatment,the 6MWT distance was significantly longer than that in the clopidogrel group,while the duration of angina pectoris in the combined medication group was significantly shorter(both P<0.01).After treatment,the cardiac index,ejection fraction and cardiac output of the combined medication group were all significantly higher than those of the clopidogrel group(all P<0.01),while the scores of physical activity limitation,frequency of angina pectoris attack,stable state of angina pectoris,treatment satisfaction and disease cognition in the combined medication group were also significantly higher than those in the clopidogrel group(all P<0.05).There were no adverse drug reactions in either of the two groups.Conclusion Compared with clopidogrel used alone,metoprolol combined with clopidogrel is more effective in shortening the duration of angina pectoris among CHD patients,improving the levels of cardiac function and quality of life,with relatively high safety.关键词
美托洛尔/氯吡格雷/冠心病/心绞痛/心功能Key words
metoprolol/clopidogrel/coronary heart disease/angina pectoris/cardiac function分类
医药卫生
