临床误诊误治2025，Vol.38Issue(6)：43-48,6.DOI:10.3969/j.issn.1002-3429.2025.06.009
血清miR-34a、TLR4水平对稳定期慢性阻塞性肺疾病患者预后的预测效能
Prognostic Efficacy of Serum miR-34a and TLR4 Levels in SCOPD Patients
摘要
Abstract
Objective To investigate the predictive efficacy of serum microRNA-34a(miR-34a)and Toll-like recep-tor 4(TLR4)on the prognosis of patients with stable chronic obstructive pulmonary disease(SCOPD).Methods A total of 107 patients with SCOPD admitted from February 2022 to February 2023 were retrospectively analyzed and followed up for 1 year.According to the clinical prognosis,the patients were divided into the good prognosis group(n=41)and the poor prog-nosis group(n=66),and the clinical data of the patients were collected to analyze the influencing factors leading to the oc-currence of poor prognosis.The predictive efficacy of serum miR-34a and TLR4 levels for poor prognosis of patients was evalu-ated.Results Compared with the good prognosis group,the poor prognosis group had significantly lower levels of FVC,FEV1,and FEV1/FVC and significantly higher levels of serum miR-34a and TLR4(P＜0.01).FVC,FEV1,FEV1/FVC,miR-34a and TLR4 levels were all influencing factors for poor prognosis of patients(P＜0.05,P＜0.01).The area under the curve of miR-34a combined with TLR4 to predict poor prognosis of SCOPD was 0.854,and the sensitivity and specificity were 86.36%and 78.05%,respectively(P＜0.01).Conclusion The levels of miR-34a and TLR4 are both influencing factors for the poor prognosis of patients with SCOPD,and they are effective indicators to predict the poor prognosis of patients.关键词
肺疾病,慢性阻塞性/微小RNA-34a/Toll样受体4/稳定期/预后/用力肺活量/第1 秒用力呼气容积Key words
Pulmonary disease,chronic obstructive/MicroRNA-34a/Toll-like receptor 4/Stable period/Prognosis/Forced vital capacity/Forced expiratory volume in one second分类
临床医学引用本文复制引用
李琪,蔡佩芬,王孟..血清miR-34a、TLR4水平对稳定期慢性阻塞性肺疾病患者预后的预测效能[J].临床误诊误治,2025,38(6):43-48,6.基金项目
江苏基层卫生发展与全科医学教育研究中心2022年度研究课题(2022B07) （2022B07）
康达学院2023年科研发展基金课题(KD2023KYJJ260) （KD2023KYJJ260）
