临床小儿外科杂志2025，Vol.24Issue(2)：125-130,6.DOI:10.3760/cma.j.cn101785-202411026-005
介入栓塞治疗儿童Galen静脉动脉瘤样畸形预后相关因素分析
Analysis of prognostic risk factors for aneurysmal malformation of the great vein of Galen in children treated with interventional embolization
摘要
Abstract
Objective To summarize the relevant clinical data to identify risk factors for the prognosis of pediatric aneurysmal malformation of great vein of Galen Galen aneurysmal malformation(VGAM)children un-dergoing interventional embolization.Methods From September 2021 to March 2023,we recruited 3 VGAM children receiving interventional treatment at our department and screened for the relevant literature items pub-lished in the electronic databases of PubMed,MEDLINE and EMBASE from January 2010 to October 2024.The relevant clinical data included age,gender,clinical symptoms,vascular structure,number of embolization events,initial embolization route,degree of embolization occlusion and prognosis.Statistical analysis was performed for i-dentifying the risk factors associated with prognosis.Results According to the inclusion and exclusion criteria,a total of 67 cases from 7 articles were eligible along with 3 children at our department for analysis.Among a total of 70 cases,65.7％(46/70)had a good prognosis after interventional embolization while 34.3％(24/70)a poor prognosi.The ratio of boy-to-girl was 48:22.There were prenatal cases(n=14),neonates(n=23)and infants &toddlers(n=33).The pre-existing conditions included heart failure(58.6％,41/70)and hydrocephalus(47.1％,33/70).The clinical types of pathological vascular structure were choroid plexus(65.7％,46/70)and wall(34.3％,24/70).The frequency of embolization was once(41.4％,29/70)and≥twice(58.6％,41/70).Initial embolization route was arterial(72.9％,51/70)and venous or dual(27.1％,19/70).Postoperative occlusion was complete(38.6％,27/70)and incomplete(61.4％,43/70).Univariate analysis revealed that de-gree of occlusion might be a predictive factor for prognosis(P=0.046).Multivariate analysis indicated that structure of diseased blood vessels(P=0.013)and degree of occlusion(P=0.046)were both related risk fac-tors for predicting prognosis.The probability of good prognosis for choroidal type was 0.175 fold that of wall type.And the probability of good prognosis for completely occluded type was 3.370 folds that of incomplete occluded type.Conclusions Interventional embolization is a preferred treatment for VGAM.And the presence of wall-like vascular structures and complete postoperative occlusion are related risk factors for good prognosis.关键词
Galen静脉动脉瘤样畸形/血管内治疗/栓塞,治疗性/治疗结果/影响因素分析/儿童Key words
Vein of Galen Aneurysmal Malformation/Endovascular Therapy/Embolization,Therapeu-tic/Treatment Outcome/Root Cause Analysis/Child引用本文复制引用
赵思琪,应建彬,陈炫杰,陈帆,张桃桃,赵清爽,荆俊杰..介入栓塞治疗儿童Galen静脉动脉瘤样畸形预后相关因素分析[J].临床小儿外科杂志,2025,24(2):125-130,6.基金项目
福建省省级临床重点专科建设项目-福建省儿童医院小儿神经外科[闽卫医政(2023)1163号] Fujian Provincial Key Clinical Specialty Construction Project:Pediatric Neurosurgery of Fujian Children's Hospital(MWYZ-2023-1163) （2023）
