临床小儿外科杂志2025，Vol.24Issue(2)：152-158,7.DOI:10.3760/cma.j.cn101785-202410047-009
胆道闭锁Kasai手术疗效及术后黄疸清除的相关因素分析
Analysis of the efficacy of Kasai surgery for biliary atresia and analysis of the related factors of postop-erative jaundice clearance
摘要
Abstract
Objective To summarize the effect of Kasai procedure of biliary atresia(BA)and explore the relevant factors affecting the clearance of postoperative jaundice.Methods The relevant clinical data were retrospectively reviewed for 340 BA children admitted from September 2015 to August 2022.There were 160 boys and 180 girls with an average age of(47.47±11.61)day.The procedures were Kasai(n=227),open surgery(n=124)and laparoscopy(n=103).Demographic profiles,surgical findings,clinical parameters and pathological examinations were recorded for examining the factors affecting the clearance of jaundice after Kasai surgery for BA.Results The final clearance of jaundice in our group of children was 65.20％(146/227)and the cumulative survival rate of native liver at 5 years after Kasai procedure 35.20％.Age(P=0.025),ultra-sonic thickness of hepatic hilar fibrous tissue(P=0.016),frequency of cholangitis episodes within 6-month postoperative period(P=0.035)and hepatic elasticity value(P=0.029)had a significant impact on jaun-dice clearance rate after Kasai's procedure.Multifactorial Logistic regression analysis of the influencing factors at P＜0.05 showed that age,ultrasonic thickness of fibrous tissue in hepatic portal,number of small bile ducts≥150 μm in diameter per unit cross-sectional area of fibrous tissue in hepatic hilar region and frequency of cholangitis episodes within 6-month postoperative period were the independent risk factors for the clearance of postoperative jaundice after Kasai procedure.Conclusions The overall outcome of jaundice clearance after Kasai procedure for BA is efficacious and it may prolong native liver survival.关键词
胆道闭锁/外科手术/Kasai手术/治疗效果/术后并发症Key words
Biliary Atresia/Surgical Procedures,Operative/Kasai Procedure/Treatment Outcome/Postoperative Complications引用本文复制引用
谢镇宇,蒲思宇,张一茂,王琦,宋九林,陈阳,向波,靳曙光..胆道闭锁Kasai手术疗效及术后黄疸清除的相关因素分析[J].临床小儿外科杂志,2025,24(2):152-158,7.基金项目
国家自然科学基金(81571473) National Natural Science Foundation of China(81571473) （81571473）
