皮肤性病诊疗学杂志2025，Vol.32Issue(2)：132-139,8.DOI:10.3969/j.issn.1674-8468.2025.02.010
皮肤微生态与皮肤屏障互作机制的研究进展
The relationship between the skin microecology and the skin barrier
摘要
Abstract
With the development of metagenomics sequencing and spatial transcriptomics,the door to the"microscopic world"of the skin surface has gradually been opened,and the"inhabit-ants"on the"habitat"of the skin have gradually become well-known.These microbial inhabitants contribute greatly to the homeostasis of the skin microenvironment by communicating with the host cells and maintaining the structural integrity and function of the skin barrier.The skin barrier does not only provide a living environment for epidermal microorganisms,but also regulates the compo-sition of the skin microbial community in terms of physics,chemistry and immunity.Therefore,disruption of the skin barrier or imbalance of the skin microbiome can profoundly impact the be-havior of host cells.The colonization of pathogenic bacteria and the loss of microbial diversity will activate the molecular signaling pathways that mediate the immune inflammatory response,resul-ting in the production and aggravation of many skin diseases,such as atopic dermatitis,acne,psoriasis,solar diseases,etc.Based on the current research status in skin microbiota,this article discusses the process of the interaction between skin microbiota and skin barrier,as well as the re-lationship between skin barrier damage and skin microbiota imbalance in the course of diseases.关键词
皮肤屏障/微生物/皮肤微生态/皮肤疾病Key words
skin barrier/microorganism/skin microbiota/skin diseases引用本文复制引用
林天一,朱慧兰,陈教全,欧珊珊,吴伟鸿,邹荟,陈紫嫣,彭丽倩,陈荃,李华平..皮肤微生态与皮肤屏障互作机制的研究进展[J].皮肤性病诊疗学杂志,2025,32(2):132-139,8.基金项目
广州市科技计划项目(2023A03J00822) （2023A03J00822）
广州市基础与应用基础研究计划市校(院)企联合资助项目(2024A03J0424) （院）
