现代畜牧兽医Issue(2)：10-14,5.DOI:10.20154/j.cnki.issn1672-9692.2025.02.003
响应面法优化盐酸头孢噻呋混悬液处方和制备工艺
Optimization of formulation and preparation process of cefotaxime hydrochloride suspension by response surface methodology
刘鹏 1冷敦鹏 1李金香 1夏伟 1李华 1韩浩1
作者信息
- 1. 青岛中仁动物药业有限公司,山东 青岛 266329
- 折叠
摘要
Abstract
The study aimed to optimize the prescription and preparation process of cefotiam hydrochloride suspension through single-factor tests and response surface methodology.The effects of the amounts of suspending agent,wetting agent,and antioxidant on the comprehensive score(Y value)of the suspension were investigated.Based on this,the Box-Behnken response surface methodology was used,selecting the amounts of suspending agent,wetting agent,and antioxidant as three factors,with the Y value as the response value.The optimal preparation process conditions for cefotiam hydrochloride suspension were determined through response surface experiments.The results showed that the optimal preparation process parameters for cefotiam hydrochloride suspension were a suspending agent amount of 3.5％,a wetting agent amount of 2.13％,and an antioxidant amount of 0.5％.Three parallel validation tests were conducted under optimal conditions,and the average value obtained for the Y value of cefotiam hydrochloride suspension was 1.21％.The study demonstrated that the method for preparing cefotiam hydrochloride suspension optimized by single-factor tests and response surface methodology was feasible.关键词
盐酸头孢噻呋/Box-Behnken响应面/混悬液Key words
Cefotiam hydrochloride/Box-Behnken response surface/Suspension分类
农业科技引用本文复制引用
刘鹏,冷敦鹏,李金香,夏伟,李华,韩浩..响应面法优化盐酸头孢噻呋混悬液处方和制备工艺[J].现代畜牧兽医,2025,(2):10-14,5.
