南京医科大学学报（自然科学版）2025，Vol.45Issue(3)：301-310,10.DOI:10.7655/NYDXBNSN241407
辅助生殖技术中的抗核抗体:临床相关性和治疗启示
Antinuclear antibodies in assisted reproductive technology:clinical relevance and therapeutic implications
摘要
Abstract
In the application of assisted reproductive technology(ART),the impact of antinuclear antibody(ANA)on the pregnancy outcomes of infertile patients has garnered attention.ANA,as a biomarker of autoimmune abnormalities,has been extensively studied for its association with unexplained infertility and its potential effects on oocyte and embryo quality.Current evidence suggests that a positive ANA status may be associated with reduced ovarian reserve function,poor embryo development,decreased clinical pregnancy rates,and increased risk of miscarriage.The level of ANA in follicular fluid is considered a sensitive indicator for predicting autoimmunity-related infertility.Specific ANA subtypes,such as anti-dsDNA antibodies and anti-centromere antibodies(ACA),are related to oocyte maturation disorder and delayed embryo development.Nevertheless,the direct link between a positive ANA status and the decline in female fertility and adverse reproductive outcomes requires further research for clarification.The review also discusses various treatment options for ANA-positive patients,including glucocorticoids,low-dose aspirin,and hydroxychloroquine,aiming to provide guidance for clinical practice and research in ART.关键词
抗核抗体/辅助生殖技术/不孕症/卵母细胞/胚胎质量/治疗Key words
antinuclear antibody/assisted reproductive technique/infertility/oocyte/embryo quality/therapy分类
基础医学引用本文复制引用
丁凯,李欣,赵纯..辅助生殖技术中的抗核抗体:临床相关性和治疗启示[J].南京医科大学学报（自然科学版）,2025,45(3):301-310,10.基金项目
国家自然科学基金(82371670) （82371670）
