南京医科大学学报（自然科学版）2025，Vol.45Issue(3)：360-366,7.DOI:10.7655/NYDXBNSN241029
基于胎盘体素内不相干运动MRI和胎儿脑体积预测生长受限胎儿中的极低出生体重儿
Prediction of very low birth weight infants in growth-restricted fetuses using intravoxel incoherent motion MRI of the placenta and fetal brain volume
摘要
Abstract
Objective:To evaluate the predictive value of placental intravoxel incoherent motion(IVIM)MRI parameters and fetal brain volume in predicting VLBWI in FGR.Methods:A retrospective analysis was conducted on 23 pregnant women with FGR,categorized into VLBWI group(n=8)and non-VLBWI group(n=15)based on birth weight.We compared brain structures as a percentage of intracranial volume and placental IVIM parameters[true diffusion coefficient(D),pseudo-diffusion coefficient(D*),perfusion fraction(f),and placental area]between the two groups.Receiver operating characteristic(ROC)curve analysis was used to assess the predictive efficacy of each parameter for VLBWI.Results:The placental D value in the VLBWI group was lower than that in the non-VLBWI group[(1.38±0.04)×10-3 mm2/s vs.(1.44±0.07)×10-3mm2/s,t=-2.109,P=0.047],and the placental area was smaller in the VLBWI group[(155.84±34.69)cm2 vs.(200.41±47.95)cm2,t=-2.315,P=0.031],while the percentage of lateral ventricle volume relative to intracranial volume was greater in the VLBWI group[(3.00±0.55)%vs.(2.53±0.33)%,t=2.591,P=0.017].The areas under the ROC curve for placental D value,placental area,and lateral ventricle as a percentage of intracranial volume were 0.767,0.783,and 0.792,respectively.Combining the fetal lateral ventricle as a percentage of intracranial volume,placental D value,and placental area improved the ROC curve area to 0.892.Conclusion:Placental IVIM parameters and fetal brain volume may serve as potentially effective imaging markers for distinguishing VLBWI in cases of FGR.关键词
胎儿生长受限/极低出生体重儿/胎儿脑体积/体素内不相干运动Key words
fetal growth restriction/very low birth weight infant/fetal brain volume/intravoxel incoherent motion分类
临床医学引用本文复制引用
孔令男,黄世杰,张璇,季亮宇,周欣,吴飞云,赵萌..基于胎盘体素内不相干运动MRI和胎儿脑体积预测生长受限胎儿中的极低出生体重儿[J].南京医科大学学报（自然科学版）,2025,45(3):360-366,7.基金项目
江苏省科教能力提升工程(JSDW202243) （JSDW202243）
