南京医科大学学报（自然科学版）2025，Vol.45Issue(3)：367-372,6.DOI:10.7655/NYDXBNSN240669
血红蛋白糖化指数与2型糖尿病患者颈动脉内膜中层厚度的相关性研究
Study on the correlation between hemoglobin glycation index and carotid intima-media thickness in patients with type 2 diabetes
摘要
Abstract
Objective:To explore the relationship between hemoglobin glycation index(HGI)and carotid intima-media thickness(cIMT)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 302 T2DM patients admitted to the Affiliated Yancheng Maternity and Child Health Hospital of Yangzhou University Medical School were enrolled.The clinical parameters including cIMT,fasting plasma glucose(FPG),and glycated hemoglobin A1c(HbA1c)were measured.HGI was calculated based on HbA1c and FPG,with high HGI defined as HGI≥0 and low HGI defined as HGI<0.The relationship between cIMT and HGI was observed.Results:Among the 302 patients with T2DM,140 cases(46.4%)had thickened cIMT.The proportion of high HGI in the cIMT thickening group was higher than that in the normal cIMT group(36.4%vs.22.8%,P<0.05).The cIMT thickening group also had longer duration of diabetes,higher smoking rate,hypertension rate,systolic blood pressure(SBP),diastolic blood pressure(DBP),HbA1c,and low-density lipoprotein cholesterol(LDL-C)levels compared to the normal cIMT group(P<0.05).The estimated glomerular filtration rate(eGFR)was lower in the cIMT thickening group(P<0.05).HbA1c and HGI were positively correlated with cIMT(r=0.257,0.399,P<0.05).Logistic regression analysis showed that both HGI and HbA1c increased the risk of cIMT thickening[OR=1.511(95%CI:1.237-1.846),OR=1.287(95%CI:1.053-1.571)].Conclusion:The prevalence of atherosclerosis is high in patients with T2DM,and HGI may be a new indicator of atherosclerosis risk in T2DM patients,beyond HbA1c.关键词
2型糖尿病/血红蛋白糖化指数/糖化血红蛋白/颈动脉内膜中层厚度/动脉粥样硬化Key words
type 2 diabetes mellitus/hemoglobin glycosylation index/glycosylated hemoglobin A1c/carotid intima-media thick-ness/atherosclerosis分类
临床医学引用本文复制引用
张成洲,陈健,孟民,李文和,任明慧,李雅洁,徐宽枫,崔岱..血红蛋白糖化指数与2型糖尿病患者颈动脉内膜中层厚度的相关性研究[J].南京医科大学学报（自然科学版）,2025,45(3):367-372,6.基金项目
国家自然科学基金(82370839) （82370839）
