南京医科大学学报（自然科学版）2025，Vol.45Issue(3)：435-442,8.DOI:10.7655/NYDXBNSN240848
LncRNA编码肽在肿瘤信号通路中的研究进展
Research progress on the role of LncRNA-encoded peptides in tumor signaling pathways
摘要
Abstract
Long noncoding RNA(LncRNA)is a class of non-coding RNA molecules,which plays an important role in gene regulation,with lengths exceeding 200 nucleotides,and is traditionally considered to lack protein-coding capacity.However,a substantial amount of recent research has revealed that LncRNA possesses coding potential,with its short open reading frame(sORF)capable of encoding functional micropeptides.These micropeptides play significant roles in various biological processes,including calcium ion homeostasis,regulation of cellular organelle metabolism,and cell differentiation.They can also impact pathological processes,such as cardiovascular diseases,inflammatory diseases,and malignant tumors,particularly by participating in multiple cellular signaling pathways that affect the occurrence,development,and metastasis of cancer.This review summarizes the research progress of LncRNA-encoded peptides in tumor signaling pathways,based on their involvement in different signaling pathways and their effect on the process of tumorigenesis and development.It discusses the potential of these peptides as biomarkers and therapeutic targets as well as points out the limitations of current research and the direction for future studies.关键词
长链非编码RNA/微肽/肿瘤/信号通路Key words
long noncoding RNA/micropeptide/tumor/signaling pathway分类
医药卫生引用本文复制引用
钱萌森,吴新雨,王科明..LncRNA编码肽在肿瘤信号通路中的研究进展[J].南京医科大学学报（自然科学版）,2025,45(3):435-442,8.基金项目
江苏科教能力提升工程 （）
江苏省医学重点学科建设单位(JSDW202235) （JSDW202235）
