内科理论与实践2024，Vol.19Issue(6)：422-426,5.DOI:10.16138/j.1673-6087.2024.06.13
间充质干细胞在系统性风湿病中的应用:现状与前景
Application of mesenchymal stem cells in systemic rheumatic diseases:current situation and prospects
摘要
Abstract
Mesenchymal stem cell(MSC),a type of cell with the ability to differentiate into multiple lineages and immunomodulatory properties,have gained widespread attention in the treatment of systemic rheumatic diseases recently.Systemic rheumatic diseases such as systemic lupus erythematosus,rheumatoid arthritis,ankylosing spondylitis,and Sjögren syndrome often led to a significant decline in patients'quality of life,while current treatment methods have limitations.Therefore,it's important to explore new method,and the application of MSC in these diseases has great significance.Current research indicates that MSC can exert therapeutic effects through various mechanisms,including regulating immune responses,promoting tissue repair,and reducing inflammation,and some clinical studies have showed the potential efficacy of MSC in systemic rheumatic diseases.However,many issues still need to be addressed,such as the source of cells,optimization of treatment protocols,and long-term safety assessments.This article systematically reviews the current application status of MSC in systemic rheumatic diseases,analyze their efficacy,safety,and future research directions,to provide a reference for development in this field.关键词
间充质干细胞/系统性风湿病/系统性红斑狼疮/干燥综合征Key words
Mesenchymal stem cell/Systemic rheumatic diseases/Systemic lupus erythematosus/Sjögren syndrome分类
医药卫生引用本文复制引用
苏传昕,朱振航,王旺,梁容珍,郑颂国,赵福涛..间充质干细胞在系统性风湿病中的应用:现状与前景[J].内科理论与实践,2024,19(6):422-426,5.基金项目
松江区科技攻关项目(2024SJKJGG070) （2024SJKJGG070）
上海市卫生健康委员会科研项目(202140411) （202140411）
