内科理论与实践2024，Vol.19Issue(6)：427-430,4.DOI:10.16138/j.1673-6087.2024.06.14
实体瘤细胞毒治疗后罹患髓系肿瘤的研究进展
An overview of myeloid neoplasms post cytotoxic therapy of solid tumors
苏琪莹 1王虹晓 1阎骅1
作者信息
- 1. 上海交通大学医学院附属瑞金医院全科医学科,上海 200025
- 折叠
摘要
Abstract
With the prolonged survival of patients with solid tumors,the incidence of myeloid neoplasms in the patients is gradually increasing after cytotoxic therapy such as chemotherapy and/or radiotherapy.The treatment efficacy and prognosis in the patients are worse than those in patients with primary myeloid neoplasms.Studies have shown that cytotoxic therapy of solid tumors may increase the risk of myeloid neoplasms,and its pathogenesis involves gene mutations,chromosomal abnormalities,and clonal hematopoiesis of indeterminate potential(CHIP).In response to the issue,researchers have proposed individualized treatment strategies,which is selecting appropriate treatment methods based on the molecular biological characteristics of tumors and the overall condition of patients.This article summarizes the incidence,prognosis,pathogenesis,and current treatment methods of myeloid neoplasms post cytotoxic therapy for solid tumors,providing important insights for guiding clinical practice and improving patient prognosis.关键词
第二原发癌/潜能未定克隆性造血/实体瘤/流行病学Key words
Second primary cance/Clonal hematopoiesis of indeterminate potential/Solid tumors/Epidemiology分类
医药卫生引用本文复制引用
苏琪莹,王虹晓,阎骅..实体瘤细胞毒治疗后罹患髓系肿瘤的研究进展[J].内科理论与实践,2024,19(6):427-430,4.
